摘要
目的探讨维生素B12(VitB12)、甲状腺激素在抑郁症患者中的表达水平及其意义。方法选取70例抑郁症患者作为观察组,70例健康体检者作为对照组,比较两组的VitB12及甲状腺激素水平,分析VitB12及甲状腺激素与抑郁症病情的关系。结果观察组的VitB12、TT_(4)、FT_(4)水平低于对照组,TSH水平高于对照组(P<0.05)。重度患者的VitB12、TT_(4)、FT_(4)水平均低于轻-中度患者,TSH水平高于轻-中度患者(P<0.05)。相关性分析显示,VitB12、TT_(4)、FT_(4)与HAMD评分呈负相关,TSH水平与HAMD评分呈正相关(P<0.05)。结论抑郁症患者的血清VitB12、TT_(4)、FT_(4)水平较低,TSH水平较高。
Objective To explore the expression levels and significance of vitamin B12(VitB12)and thyroid hormones in patients with depression.Methods 70 patients with depression were selected as the observation group,and 70 healthy subjects were selected as the control group.The levels of VitB12 and thyroid hormones were compared between the two groups,and the relationships of VitB12 and thyroid hormones with the disease state of depression were analyzed.Results The levels of VitB12,TT and FT_(4) in the observation group were lower than those in the control group,and the TSH level was higher than that in the control group(P<0.05).The levels of VitB12,TT_(4) and FT_(4) in severe patients were lower than those in mild-moderate patients,and the TSH level was higher than that in mild-moderate patients(P<0.05).Correlation analysis showed that VitB12,TT_(4) and FT_(4) were negatively correlated with HAMD score,and TSH level was positively correlated with HAMD score(P<0.05).Conclusions Patients with depression have lower levels of serum VitB12,TT_(4) and FT_(4),and high level of TSH.
作者
姜云
李瑞丽
JIANG Yun;LI Ruili(Clinical Laboratory,Jiaozuo Psychiatric Hospital,Jiaozuo 454000,China;Clinical Laboratory,Jiaozuo Central Blood Station,Jiaozuo 454000,China)
出处
《临床医学工程》
2023年第8期1111-1112,共2页
Clinical Medicine & Engineering
