摘要
目的:观察奥扎格雷联合阿司匹林和静脉溶栓治疗急性脑梗死患者的效果。方法:选取2021年2月至2022年12月该院收治的98例急性脑梗死患者进行前瞻性研究,按照随机数字表法分为观察组与对照组各49例。对照组给予静脉溶栓和阿司匹林抗血小板治疗,观察组在对照组基础上联用注射用奥扎格雷钠治疗,比较两组疗效、美国国立卫生院卒中量表(NIHSS)评分、Barthel指数(BI)评分、血液流变学指标(血浆黏度、全血低切黏度、全血高切黏度)水平和不良反应发生率。结果:观察组治疗总有效率为93.88%,明显高于对照组的75.51%,差异有统计学意义(P<0.05);治疗后,观察组NIHSS评分和血浆黏度、全血低切黏度、全血高切黏度低于对照组,BI评分高于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:奥扎格雷联合阿司匹林和静脉溶栓治疗急性脑梗死患者可提高治疗总有效率和BI评分,降低NIHSS评分、血浆黏度、全血低切黏度、全血高切黏度,效果优于静脉溶栓联合阿司匹林治疗。
Objective:To observe effects of Ozagrel combined with Aspirin and intravenous thrombolysis in treatment of patients with acute cerebral infarction.Methods:A prospective study was conducted on 98 patients with acute cerebral infarction admitted to this hospital from February 2021 to December 2022.They were divided into observation group and control group according to the random number table method,49 cases in each group.The control group was treated with intravenous thrombolysis and Aspirin antiplatelet therapy,while the observation group was treated with sodium Ozagrel for injection on the basis of that of the control group.The efficacy,the National Institutes of Health stroke scale(NIHSS)score,the Barthel index(BI)score,the hemorheology index levels(plasma viscosity,whole blood low shear viscosity,whole blood high shear viscosity),and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 93.88%,which was significantly higher than 75.51% in the control group,and the difference was statistically significant(P<0.05).After the treatment,the NIHSS score,the plasma viscosity,the whole blood low shear viscosity and the whole blood high shear viscosity in the observation group were lower than those in the control group,the BI score was higher than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ozagrel combined with Aspirin and intravenous thrombolysis in the patients with acute cerebral infarction can improve the total effective rate of treatment and the BI scores reduce the NIHSS scores and the plasma viscosity,the whole blood low shear viscosity,the whole blood high shear viscosity.Moreover,it is superior to intravenous thrombolysis combined with Aspirin.
作者
王婷
WANG Ting(th Ward of Department of Neurology of the First Affiliated Hospital of Nanyang Medical College,Nanyang 473000 Henan,China)
出处
《中国民康医学》
2023年第14期29-31,共3页
Medical Journal of Chinese People’s Health
关键词
急性脑梗死
奥扎格雷
阿司匹林
静脉溶栓
血流流变学
神经功能缺损
不良反应
Acute cerebral infarction
Ozagrel
Aspirin
Intravenous thrombolysis
Hemorheology
Neurological deficit
Adverse reaction
