摘要
慢性萎缩性胃炎(CAG)是消化系统常见病、疑难病,以胃黏膜腺体减少或消失为特征,CAG出现肠上皮化生或异型增生被称为胃癌前病变,大大增加癌变风险。核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体激活失调释放大量炎症因子,诱导炎症级联反应,参与多种疾病进程。研究发现NLRP3炎症小体激活失调会引起胃黏膜长期慢性炎症浸润,诱导CAG发生发展,而线粒体功能障碍在NLRP3炎症小体激活过程中扮演重要角色,线粒体功能障碍产生活性氧(ROS)堆积是激活NLRP3炎症小体的关键。刘友章教授提出“脾-线粒体相关”理论,认为脾主运化水谷,化生气血,将营养物质输送至全身,供给机体所需能量和物质;线粒体通过三羧酸循环生成的三磷酸腺苷(ATP)是人体的主要能量来源,二者在生理上作为人体能量加工厂的观点不谋而合,在病理上脾虚与线粒体氧化磷酸化功能障碍存在关联,脾虚不运出现湿浊痰瘀等病理产物与线粒体功能障碍产生的代谢产物等存在契合之处。该研究从“脾-线粒体相关”理论出发,探讨CAG的中医病机,论述了NLRP3炎症小体与CAG发病的关系,提出线粒体功能障碍激活NLRP3炎症小体是CAG脾虚病机的现代生物学基础,健脾法可能与改善CAG患者线粒体功能和炎症反应,减轻胃黏膜损伤有关,为中医药防治CAG提供新思路。
Chronic atrophic gastritis(CAG)is a common and intractable disease in the digestive system characterized by the reduction or disappearance of gastric mucosal glands.The intestinal metaplasia or dysplasia in CAG is called precancerous lesion,which greatly increases the risk of cancerization.Dysactivation of nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammatory corpuscles can release a large number of inflammatory factors,induce inflammatory cascade reactions,and participate in the process of many diseases.As reported,the dysactivation of NLRP3 inflammatory corpuscles can cause long-term chronic inflammatory infiltration of gastric mucosa and induce the development of CAG.Mitochondrial dysfunction plays an important role in the activation of NLRP3 inflammatory corpuscles.The accumulation of reactive oxygen species(ROS)produced by mitochondrial dysfunction is the key to activating NLRP3 inflammatory corpuscles.Professor LIU Youzhang put forward the theory of"spleen-mitochondrion correlation",which holds that the spleen mainly transports water and grains,generates qi and blood,transports nutrients to the whole body,and supplies energy and materials needed by the body.Adenosine triphosphate(ATP)generated by mitochondria through the circulation of tricarboxylic acid is the main energy source of the human body.The view that both of them serve as human energy processing plants coincides in terms of physiology.Pathologically,spleen deficiency is associated with mitochondrial oxidative phosphorylation dysfunction.Pathological products such as dampness,turbidity,phlegm,and blood stasis due to failure in transportation because of spleen deficiency are consistent with metabolites generated by mitochondrial dysfunction.Based on the theory of"spleen-mitochondrion correlation",this study discussed the pathogenesis of CAG in traditional Chinese medicine(TCM),analyzed the relationship between NLRP3 inflammatory corpuscles and the pathogenesis of CAG,and proposed that the activation of NLRP3 inflammat
作者
黎秀娟
黎丽群
马超北
王玉燕
付文静
刘芙蓉
钟焕英
刘礼剑
LI Xiujuan;LI Liqun;MA Chaobei;WANG Yuyan;FU Wenjing;LIU Furong;ZHONG Huanying;LIU Lijian(Guangxi University of Chinese Medicine,Nanning 530001,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530001,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第17期267-273,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(82160877)
广西中医脾胃病临床医学研究中心(桂科AD19245168)。
