摘要
目的 研究小半夏加茯苓汤联合巴氯芬治疗缺血性脑卒中(IS)后顽固性呃逆的疗效。方法 收集肇庆市中医院内科2020年7月-2022年1月IS后顽固性呃逆患者60例,以随机数字表法分配患者至对照组与观察组,每组各30例。两组均予巴氯芬治疗,同时对照组予奥美拉唑治疗,观察组则予小半夏加茯苓汤治疗,两组均连续治疗7 d。观察两组患者治疗前后中医证候评分。检测两组患者治疗前后胃蛋白酶原(PG)-Ⅰ与PG-Ⅱ血清水平。观察两组患者不良反应发生情况与治疗后1个月复发情况。结果 观察组总有效率为93.33%,高于对照组(70.00%),差异有统计学意义(P <0.05);观察组显效率为63.33%,高于对照组(36.67%),差异有统计学意义(P <0.01)。观察组治疗后中医证候评分明显少于对照组,差异有统计学意义(P <0.01)。两组治疗后PG-Ⅰ血清水平比较,差异无统计学意义(P> 0.05),但观察组治疗后PG-Ⅱ血清水平低于对照组,差异有统计学意义(P <0.05)。治疗后1个月,观察组复发率为6.67%,低于对照组(36.67%),差异有统计学意义(P <0.05)。结论 小半夏加茯苓汤联合巴氯芬可有效改善IS后顽固性呃逆患者的中医证候,其作用与抑制PG-Ⅱ有关。
Objective To study the therapeutic efficacy of Xiaobanxia modified with Fuling Decoration combined with Baclofen in the treatment of intractable hiccup after ischemic stroke(IS).Methods Sixty patients with intractable hiccup after IS admitted to the Department of Internal Medicine at Zhaoqing Hospital of Traditional Chinese Medicine from July 2020 to January 2022 were randomly assigned to the control group and the observation group,with 30 patients in each group.Both groups received Baclofen treatment.The control group received omeprazole treatment,and the observation group received Xiaobanxia modified with Fuling Decoration.Both groups were treated continuously for 7 days.The TCM syndrome scores of the patients in both groups were observed before and after treatment.The serum levels of pepsinogen I(PG-I)and pepsinogen II(PG-II)were measured before and after treatment in both groups.Adverse reactions and recurrence within one month after treatment were observed in both groups.Results The total effective rate in the observation group was 93.33%,which was higher than 70.00%in the control group(P<0.05).The markedly effective rate in the observation group was 63.33%,which was higher than 36.67%in the control group(P<0.01).The TCM syndrome scores in the observation group after treatment were significantly lower than those in the control group(P<0.01).There was no statistically significant difference in serum PG-I levels between the two groups after treatment(P>0.05),but the serum PG-II level in the observation group was lower than that in the control group(P<0.05).After one month of treatment,the recurrence rate in the observation group was 6.67%,which was lower than 36.67%in the control group(P<0.05).Conclusion Xiaobanxia modified with Fuling Decoration combined with Baclofen can effectively improve the TCM syndrome of patients with intractable hiccup after IS,and its mechanism may be related to the inhibition of PG-II.
作者
余乐端
陈杰夫
娄勍
YU Leduan;CHEN Jiefu;LOU Qing(Zhaoqing Hospital of Traditional Chinese Medicine,Zhaoqing 526000,China)
出处
《基层中医药》
2023年第7期46-51,共6页
Basic Traditional Chinese Medicine
基金
肇庆市科技创新指导类项目(202004030738)。
关键词
小半夏加茯苓汤
巴氯芬
缺血性脑卒中
顽固性呃逆
中西医结合治疗
Xiaobanxia modified with Fuling Decoration
Baclofen
ischemic stroke
intractable hiccup
treatment with TCM and western medicine
