摘要
卵巢癌(ovarian carcinoma,OC)是女性患病率和致死率相对较高的肿瘤,其中上皮性卵巢癌(epithelial ovarian cancer,EOC)诊断率明显高于其他类型的OC。EOC的产生与乳腺癌易感基因(breastcancer susceptibility gene,BRCA)有明显的关联性。BRCA基因是一种恶性肿瘤易感基因,可以调整DNA损伤修补,保持细胞生长和细胞凋亡,保持细胞基因遗传稳定性。BRCA基因突变会明显增加患EOC风险,与此同时,BRCA基因影响着EOC的临床诊治、病理和愈后等。具备BRCA基因突变的EOC(BMOC)对铂类DNA损伤剂以及聚腺苷二磷酸核糖聚合酶抑制剂(PARPi)治疗更加敏感。临床上以BRCA基因为主对卵巢癌患者进行多基因检验,可以为卵巢癌的发病机制、风险评价、治疗和愈后提供临床基础。融合最新研究成果,文中就BRCA基因的基本情况以及BRCA基因与上皮性卵巢癌具体关联性作一具体综述。
Ovarian carcinoma(OC)is a tumor with relatively high morbidity and mortality in women,and the diagnosis rate of epithelial ovarian cancer(EOC)is significantly higher than that of other types of OC.The production of EOC has obvious correlation with breast cancer susceptibility gene(BRCA).BRCA gene is a malignant tumor susceptibility gene,which can adjust DNA damage repair,maintain cell growth and apoptosis,and maintain the genetic stability of cell genes.BRCA gene mutation can significantly increase the risk of EOC.At the same time,BRCA gene affects the clinical diagnosis and treatment,pathology and prognosis of EOC.EOC with BRCA mutations(BMOC)are more sensitive to platinum-based DNA-damaging agents and poly(ADP-ribose)polymerase inhibitor(PARPi)therapy.Clinically,polygenic testing of ovarian cancer patients with BRCA gene as the main gene can provide a clinical basis for the pathogenesis,risk assessment,treatment and prognosis of ovarian cancer.Combined with the latest research results,this paper makes a specific review on the basic situation of BRCA gene and the specific correlation between BRCA gene and epithelial ovarian cancer.
作者
周宇恒
Zhou Yuheng(Department of Medicine,Xinglin College,Nantong University,Nantong Jiangsu,226236,China)
出处
《中外女性健康研究》
2023年第14期21-24,共4页
Women＇s Health Research
