摘要
目的探究2017年—2021年开封市儿童医院血培养中细菌分布及耐药性情况,以指导临床合理使用抗生素。方法对2017年—2021年开封市儿童医院血培养阳性的检出菌和药敏结果进行回顾性分析。结果共收集538例血培养阳性住院患儿的资料纳入研究,年龄分布0~14岁,其中年龄最大的为14岁,最小的为0 d,所有患儿以新生儿组(0~28 d)最多为280例,占比52.04%;季节分组中春季(3~5月)、夏季(6~8月)、秋季(9~11月)、冬季(12月~次年2月)各124例(23.05%)、140例(26.02%)、127例(23.61%)、147例(27.32%);男性患儿328例(60.97%),女性患儿210例(39.03%),男性患儿比例高于女性患儿(P<0.05);在科室分组中,新生儿病区167例(31.04%),占比最高。538株血培养阳性标本中,凝固酶阴性葡萄球菌226株,占比最高为42.01%,其次分别为金黄色葡萄球菌、大肠埃希菌、肺炎克雷伯菌、沙门菌以及肺炎链球菌,分别为48株(8.92%)、46株(8.55%)、45株(8.36%)、22株(4.09%)和20株(3.72%)。凝固酶阴性葡萄球菌对青霉素、氨苄西林、苯唑西林的耐药率分别为99.12%、96.46%和92.92%;金黄色葡萄球菌对青霉素、氨苄西林、红霉素的耐药率分别为100.00%、100.000%和85.42%;屎肠球菌对红霉素、青霉素、四环素、氨苄西林的耐药率分别为93.75%、87.50%、81.25%和81.25%。大肠埃希菌对氨苄西林、复方新诺明的耐药率分别为89.13%、89.13%;肺炎克雷伯菌对氨苄西林、哌拉西林、头孢呋辛的耐药息率分别为95.56%、88.99%和84.44%;沙门菌对环丙沙星、氨苄西林的耐药率分别为100.00%和81.82%;阴沟肠杆菌对氨苄西林的耐药率为83.33%;铜绿假单胞菌对复方新诺明、四环素的耐药率分别为80.00%、80.00%。结论2017年—2021年某院儿童血培养的病原菌以凝固酶阴性葡萄球菌感染为主,常见病原菌对抗菌药物的耐药性较高。
Objective To investigate the distribution and drug resistance of bacteria in blood culture in Kaifeng Childrens Hospital from 2017 to 2021,so as to guide the rational use of antibiotics in clinic.Methods sRetrospective analysis was conducted on positive blood culture bacteria and drug sensitivity in Kaifeng Childrens Hospital from 2017 to 2021.ResultsA total of 538 hospitalized children with positive blood culture were collected and included in the study,ranging in age from 0 to 14 years old,among which the oldest was 14 years old and the youngest was O d.Among all the children,the maximum number of cases was 280 in the neonatal group(0-28D),accounting for 52.04%.There were 124 cases(23.05%)in spring(March to May),140 cases(26.02%)in summer(June to August),127 cases(23.61%)in autumn(September to November)and 147 cases(27.32%)in winter(December to February),respec-tively.There were 328 cases(60.97%)of male children and 210 cases(39.03%)of female children.The proportion of male children was higher than that of female children(P<0.05).Among the departments,167 cases(31.04%)were in neonatal ward,accounting for the highest proportion.Among 538 strains of positive blood culture samples,226 strains of coagulase negative staphylococcus accounted for 42.01%,followed by Staphylococcus aureus,Escherichia co-li,Klebsiella pneumoniae,Salmonella and Streptococcus pneumoniae.They were 48(8.92%),46(8.55%),45(8.36%),22(4.09%)and 20(3.72%).The resistance rates of coagulase negative staphylococcus to penicillin,ampicillin and benzacillin were 99.12%,96.46%and 92.92%,respectively.The resistance rates of Staphylococcus aureus to penicillin,ampicillin and erythromycin were 100.00%,100.000%and 85.42%,respectively.The resistance rates of Enterococcus faecium to erythromycin,penicillin,tetracycline and ampicillin were 93.75%,87.50%,81.25%and 81.25%,respectively.The resistance rates of Escherichia coli to ampicillin and cotrimoxazole were 89.13%and 89.13%,respectively.The rate of resistance of Klebsiella pneumoniae to ampicillin,piperacil
作者
张聪慧
王芳
ZHANG Cong-hui;WANG Fang(Department of Clinical Laboratory,Kaifeng Childrens Hospital,Kaifeng,Henan 475000,China)
出处
《医药论坛杂志》
2023年第11期92-95,共4页
Journal of Medical Forum
关键词
血培养
病原菌
耐药性
儿童
Blood culture
Pathogenic bacteria
Drug resistance
Children
