摘要
目的:分析学龄期大叶性肺炎患儿病原菌分布及耐药性。方法:回顾性分析2019年9月至2021年9月该院收治的108例学龄期大叶性肺炎患儿的临床资料。留取患儿痰标本并完成细菌培养,分离和鉴定病原菌后,进行药敏试验。统计病原菌分布情况,并分析其耐药性。结果:108例学龄期大叶性肺炎患儿痰标本共分离得到108株病原菌,其中革兰阴性菌63株(58.33%),以大肠埃希菌为主,肺炎克雷伯菌次之;革兰阳性菌45株(41.67%),以肺炎链球菌为主,金黄色葡萄球菌次之;大肠埃希菌对氨苄西林、头孢呋辛耐药性为11/17、10/17,对亚胺培南耐药性为1/17;肺炎克雷伯菌对氨苄西林、头孢哌酮耐药性为6/10、5/10,对阿米卡星、亚胺培南耐药性为0;铜绿假单胞菌对头孢唑林耐药性为9/9,对头孢哌酮、头孢吡肟、阿米卡星、环丙沙星耐药性为0;肺炎链球菌对红霉素耐药性较高(71.43%),对头孢噻肟耐药性较低(4.76%);金黄色葡萄球菌对头孢曲松、头孢噻肟耐药性为9/12、8/12,对亚胺培南耐药性为0、氨苄西林耐药性为1/12。结论:学龄期大叶性肺炎患儿病原菌较多,肺炎链球菌为其主要病原菌,且各病原菌耐药性不同,临床需结合药敏试验选取适宜药物,以增强抗菌效果。
Objective:To analyze pathogenic bacteria distribution and drug resistance in school-age children with lobar pneumonia.Methods:The clinical data of 108 school-age children with lobar pneumonia admitted to the hospital from September 2019 to September 2021 were retrospectively analyzed.The sputum samples were collected and the bacterial culture was completed.After isolation and identification of the pathogenic bacteria,the drug sensitivity test was carried out.The distribution of pathogenic bacteria was statistically analyzed and their drug resistance was analyzed.Results:A total of 108 strains of pathogenic bacteria were isolated from the sputum samples of the 108 school-age children with lobar pneumonia,including 63 strains of Gram-negative bacteria(58.33%),mainly Escherichia coli,followed by Klebsiella pneumoniae;and 45 strains of Gram-positive bacteria(41.67%),mainly Streptococcus pneumoniae,followed by Staphylococcus aureus.The resistance rates of Escherichia coli to Ampicillin and Cefuroxime were 11/17 and 10/17,respectively,and the resistance rate to Imipenem was 1/17.The resistance of Klebsiella pneumoniae to Ampicillin and Cefoperazone was 6/10 and 5/10,and the resistance to Amikacin and Imipenem was 0.The resistance of Pseudomonas aeruginosa to Cefazolin was 9/9,and the resistance to Cefoperazone,Cefepime,Amikacin and Ciprofloxacin was 0.Streptococcus pneumoniae had higher resistance to Erythromycin(71.43%)and lower resistance to Cefotaxime(4.76%).The resistance of Staphylococcus aureus to Ceftriaxone and Cefotaxime was 9/12 and 8/12,the resistance to Imipenem was 0,and the resistance to Ampicillin was 1/12.Conclusions:There are many pathogenic bacteria in the school-age children with lobar pneumonia.Streptococcus pneumoniae is the main pathogenic bacteria,and the drug resistance of each pathogenic bacteria is different.Clinically,appropriate drugs should be selected in combination with the drug sensitivity test to enhance the therapeutic effects.
作者
李智
LI Zhi(Department of Clinical Laboratory of Xuchang Central Hospital,Xuchang 461000 Henan,China)
出处
《中国民康医学》
2023年第13期140-142,共3页
Medical Journal of Chinese People’s Health
关键词
大叶性肺炎
学龄期儿童
病原菌分布
耐药性
抗生素
Lobar pneumonia
School-age children
Pathogenic bacteria distribution
Drug resistance
Antibacterial drug
