摘要
目的分析可根治性切除胃印戒细胞癌患者术前白蛋白与纤维蛋白原比值对预后的预测价值。方法回顾性分析行根治性切除术胃印戒细胞癌的173例患者的临床病例资料。绘制受试者工作特征(ROC)曲线计算白蛋白/纤维蛋白原比值(AFR)临界值,分为低AFR组(n=50)和高AFR组(n=123),对比2组临床病理资料及不同AFR表达水平总生存期(OS)的差异,采用Cox回归分析对胃印戒细胞癌患者预后因素进行单多因素分析。结果AFR预测胃印戒细胞癌患者预后的ROC曲线下面积0.603(95%CI:0.512~0.695,P<0.05),最佳截断值为11.49,敏感度和特异度分别为0.44和0.79(P<0.05)。AFR低水平组与AFR高水平组在患者年龄、肿瘤直径、肿瘤部位、肿瘤T分期、TNM分期、Borrmann分型上差异有统计学意义(P<0.05)。低AFP组患者的3年、5年累积生存率分别为50.8%和40.3%,高AFR组患者的3年及5年累积生存率分别为72.0%和65.3%,低AFR组患者的预后明显差于高AFR组患者(P<0.05)。单因素Cox回归分析结果显示,年龄、术前贫血、肿瘤大小、T分期、TNM分期及术前AFR影响胃印戒细胞癌患者预后(P<0.05);多因素Cox回归分析结果显示,年龄及术前AFR是胃癌患者预后的独立危险因素(P<0.05)。结论术前AFR是胃印戒细胞癌患者的独立预后因素,术前低水平AFR患者预后不佳,为其应用于预测胃印戒细胞癌患者的长期生存提供了临床依据。
Objective To investigate the prognostic value of albumin/fibrinogen ratio(AFR)in patients with gastric signet ring cell carcinoma(GSRCC).Methods A retrospective study was performed on 173 cases of patients with GSRCC who underwent radical resection.Albumin and fibrin were detected by the automatic biochemical analyzer.The cut-off values of AFR were determined by drawing the subject work characteristic curve,and the patients were divided into high(n=123)and low(n=50)levels according to the cut-off values of AFR.The clinicopathological characteristics of GSRCC patients with different AFR expression levels were analyzed to compare the survival rates of GSRCC patients with different AFR expression levels and Cox regression analysis was used to analyze the prognostic factors of patients with GSRCC carcinoma.Results The area under the ROC curve of AFR for predicting the prognosis of patients with GSRCC was 0.603(95%CI:0.512~0.695,P<0.05),the cutoff value was 11.49,and the sensitivity and specificity were respectively 0.44 and 0.79(P<0.05).There were significant differences in age,tumor diameter,tumor location,tumor T stage,TNM stage,and Borrmann classification between the low-level AFR group and the high-level AFR group(P<0.05).The 3-year and 5-year cumulative survival rates of the patients in the low AFP group were 50.8%and 40.3%,respectively,and the 3-year and 5-year cumulative survival rates of the patients in the high AFP group were 72.0%and 65.3%,respectively.The prognosis of the patients in the low AFP group was significantly worse.Univariate Cox regression analysis showed that age,preoperative anemia,tumor size,T stage,TNM stage and preoperative AFR affected the prognosis of patients with GSRCC(P<0.05).AFR was an independent risk factor for the prognosis of GSRCC patients(P<0.05).Conclusion Preoperative AFR is an independent prognostic factor for patients with GSRCC.Patients with low preoperative AFR level have poor prognosis,which provides a clinical basis for its application in predicting the long-term surviva
作者
罗梦
马小兰
杨海鹏
叶晓锋
黄凌燕
LUO Meng;MA Xiaolan;YANG Haipeng;YE Xiaofeng;HUANG Lingyan(Department of Gynecology,Yinchuan,Maternal and Child Health Hospital,Yinchuan,750004,China;Ningxia Medical University,Yinchuan 750004,China;Department of Oncology,General Hospital of Ningxia Medical University,Yinchuan 750004,China;Department of Pathology,General Hospital of Ningxia Medical University,Yinchuan 750004,China)
出处
《宁夏医学杂志》
CAS
2023年第7期596-599,F0003,共5页
Ningxia Medical Journal
关键词
白蛋白与纤维蛋白原比值
胃印戒细胞癌
临床病理特征
预后
Albumin to fibrin ratio
Gastric signet ring cell carcinoma
Clinicopathological features
Prognosis
