摘要
目的探讨拉贝洛尔联合硝苯地平治疗妊娠期高血压疾病(HDCP)患者的效果。方法选取2020年5月至2021年6月收治的200例HDCP患者为研究对象,将其随机分为对照组和观察组,各100例。对照组给予硝苯地平治疗,观察组在对照组基础上给予拉贝洛尔治疗。比较两组的临床效果。结果治疗后,观察组的收缩压(SBP)、舒张压(DBP)、尿蛋白含量低于对照组(P<0.05)。治疗后,观察组的内皮素-1(ET-1)、血管性血友病因子(v WF)水平低于对照组,前列环素(PGI2)、一氧化氮(NO)水平高于对照组(P<0.05)。治疗后,观察组的活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)长于对照组,D-二聚体(D-D)、纤维蛋白降解产物(FDP)水平低于对照组(P<0.05)。观察组的新生儿、产妇不良结局总发生率低于对照组,差异具有统计学意义(P<0.05)。结论拉贝洛尔联合硝苯地平治疗HDCP能有效降低血压,改善血管内皮功能及凝血纤溶功能,提高母婴安全性,值得推广。
Objective To investigate the effect of labetalol combined with nifedipine in the treatment of hypertensive disorder complicating pregnancy(HDCP).Methods A total of 200 patients with HDCP admitted from May 2020 to June 2021 were selected as the study objects and randomly divided into control group and observation group,with 100 cases in each group.The control group was treated with nifedipine,and the observation group was treated with labetalol on the basis of the control group.The clinical effects of the two groups were compared.Results After treatment,the systolic blood pressure(SBP),diastolic blood pressure(DBP)and urinary protein content in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of endothelin-1(ET-1)and von Willebrand factor(vWF)in the observation group were lower than those in the control group,and the levels of prostacyclin(PGI2)and nitric oxide(NO)were higher than those in the control group(P<0.05).After treatment,the activated partial thromboplastin time(APTT)and prothrombin time(PT)of the observation group were longer than those of the control group,and the levels of D-dimer(D-D)and fibrin degradation product(FDP)were lower than those of the control group(P<0.05).The total incidences of adverse outcomes in newborns and postpartum women in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Labetalol combined with nifedipine in the treatment of HDCP can effectively reduce blood pressure,improve vascular endothelial function,coagulation and fibrinolysis function,and improve the safety of mothers and infants,which is worth popularizing.
作者
李淑馨
高瑞
LI Shuxin;GAO Rui(Obstetrics Department,Yulin No.2 Hospital,Yulin 719000;Gynecology and Obstetrics Department,the First Hospital of Yulin,Yulin 719000,China)
出处
《临床医学研究与实践》
2023年第23期129-132,共4页
Clinical Research and Practice
关键词
妊娠期高血压疾病
拉贝洛尔
硝苯地平
血管内皮功能
凝血纤溶功能
hypertensive disorder complicating pregnancy
labetalol
nifedipine
vascular endothelial function
coagulation and fibrinolysis function
