摘要
目的 分析超声引导聚桂醇联合米非司酮对子宫肌瘤患者卵巢功能及血流动力学的影响。方法 收集2019年8月至2021年8月在浙江省台州医院进行诊治的80例子宫肌瘤患者,分为对照组与研究组各40例。对照组采用超声引导下注射聚桂醇治疗,研究组在对照组基础上口服米非司酮,对比两组患者的肌瘤体积、直径、血管内皮功能指标、血清炎症因子水平、卵巢功能指标、血流动力学、不良反应、治疗疗效。结果 与治疗前比较,治疗后的肌瘤体积、直径缩小,且研究组的缩小幅度较大(P<0.05);与治疗前比较,治疗后血管内皮生长因子(vascular endothelial growth factor,VEGF)、碱性成纤维细胞生长因子(basic fibroblast growth factor,BFGF)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、基质金属蛋白酶9(matrix metalloproteinase 9,MMP-9)、胰岛素样生长因子1(insulin-like growth factor 1,IGF-1)、雌二醇(estradiol,E2)、促卵泡激素(follicle-stimulating hormone,FSH)、促黄体生成素(luteinizing hormone,LH)、子宫动脉收缩期最大流速(maximum systolic velocity of uterine artery,V_(max))、舒张末期流速(minimum blood flow velocity at the end of diastole,V_(min))水平降低,阻力指数(resistance index,RI)水平升高,且研究组的降低/升高幅度较大(P<0.05);研究组的治疗总有效率较高(P<0.05)。结论 超声引导聚桂醇、米非司酮共同使用效果较好,可对子宫肌瘤患者的卵巢功能进行调节,降低炎症因子水平,改善患者的血流动力学,临床治疗效果较好。
Objective To analyze the effect of ultrasound guided lauromacrogol combined with mifepristone on ovarian function and hemodynamics in patients with uterine fibroids.Methods A total of 80 patients with uterine fibroids diagnosed and treated in Taizhou Hospital of Zhejiang Province from August 2019 to August 2021 were collected and divided into control group and study group,with 40 cases in each group.The control group was treated with ultrasound-guided injection of lauromacrogol,while the study group was treated with oral mifepristone on the basis of control group.The fibroid volume,diameter,vascular endothelial function index,serum inflammatory factor level,ovarian function index,hemodynamics,adverse reactions and treatment efficacy were compared between the two groups.Results Compared with before treatment,the volume and diameter of fibroids decreased after treatment,and the study group showed a significant reduction(P<0.05);Compared with that before treatment,after treatment,vascular endothelial growth factor(VEGF),basic fibroblast growth factor(BFGF),tumor necrosis factor-α(TNF-α),matrix metalloproteinase 9(MMP-9),insulin-like growth factor 1(IGF-1),estradiol(E2),follicle-stimulating hormone(FSH),luteinizing hormone(LH),maximum systolic velocity of uterine artery(Vmax),minimum blood flow velocity at the end of diastole(Vmin)level decreased,while the resistance index(RI)level increased,with a significant decrease/increase in the study group(P<0.05);The total effective rate of the study group was relatively high(P<0.05).Conclusion The combined use of ultrasound-guided lauromacrogol and mifepristone has a good effect,which can regulate the ovarian function of patients with uterine fibroids,reduce the level of inflammatory factors,improve the hemodynamics of patients,and has a good clinical treatment effect.
作者
罗曼蔚
朱峥峥
LUO Manwei;ZHU Zhengzheng(Department of Ultrasound,Taizhou Hospital Affiliated to Wenzhou Medical University,Taizhou Hospital of Zhejiang Province,Linhai 317000,Zhejiang,China;Department of Obstetrics,Taizhou Hospital Affiliated to Wenzhou Medical University,Taizhou Hospital of Zhejiang Province,Linhai 317000,Zhejiang,China)
出处
《中国现代医生》
2023年第21期64-68,共5页
China Modern Doctor
关键词
超声
聚桂醇
米非司酮
子宫肌瘤
卵巢功能
血流动力学
Ultrasound
Lauromacrogol
Mifepristone
Uterine fibroids
Ovarian function
Hemodynamics
