摘要
目的:分析醒脾养儿颗粒联合布拉氏酵母菌对轮状病毒性肠炎肠道菌群及炎症因子的影响。方法:前瞻性纳入2019年10月至2021年10月我院收治的80例轮状病毒性肠炎患儿,随机分为观察组和对照组(n=40)。对照组给予布拉氏酵母菌1袋·次^(-1),1次·d^(-1),连续治疗5 d。观察组在对照组基础上加醒脾养儿颗粒,均连续治疗5 d。治疗5 d后,比较两组临床治疗效果;于治疗前、治疗5 d后,采用实时荧光定量PCR(Real-time quantitative polymerase chain reaction,PCR)法测定双歧杆菌、乳酸杆菌、大肠杆菌数量;采用酶联免疫吸附法检测肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、白细胞介素-6(Interleukin-6,IL-6)、白细胞介素-10(Interleukin-10,IL-10)水平;并比较治疗期间两组不良反应发生率。结果:治疗5 d后,观察组总有效率高于对照组(P<0.05);与治疗前相比,治疗5 d后两组双歧杆菌和乳酸杆菌数量增加,大肠杆菌数量减少,TNF-α、IL-6及IL-10水平均降低(P<0.05),其中观察组更为显著(P<0.05);两组不良反应比较,差异无统计学意义(P>0.05)。结论:布拉氏酵母菌联合醒脾养儿颗粒治疗轮状病毒性肠炎患者可改善患者肠道菌群,减轻炎症反应。
Objective:To analyze the effects of Xingpi Yanger granule combined with Saccharomyces boulardii on intestinal flora and inflammatory factors of rotavirus enteritis.Methods:A total of 80 children with rotavirus enteritis admitted to our hospital from October 2019 to October 2021 were prospectively included and randomly divided into the observation group and the control group(n=40).The control group was given Saccharomyces boulardii,one bag per time,once a day,for 5 consecutive days.The observation group added Xingpi Yanger granules based on the control group.After 5 days of treatment,the clinical effects of the two groups were compared.The numbers of bifidobacteria,lactobacillus,and escherichia coli were determined by real-time fluorescent quantitative PCR before and 5 days after treatment.The levels of inflammatory factors,including tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-10(IL-10)were detected by enzyme-linked immunosorbent assay.The incidence of adverse reactions during treatment was compared between the two groups.Results:After 5 days of treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05).Compared with before treatment,the number of bifidobacteria,lactobacillus increased,the number of escherichia coli decreased,and the levels of TNF-α,IL-6,and IL-10 were significantly decreased in the two groups after 5 days of treatment(P<0.05),especially the observation group(P<0.05).However,there was no statistical significant difference in adverse reactions in both groups(P>0.05).Conclusion:Saccharomyces boulardii combined with Xingpi Yang'er granule can improve the intestinal flora of patients with rotavirus enteritis and reduce inflammatory reactions.
作者
牛凤玲
肖心怡
Niu Feng-ling;Xiao Xin-yi(Department of Pediatrics,Xinyang Maternal and Child Health Care Hospital,Xinyang 464000,Henan,China)
出处
《四川生理科学杂志》
2023年第8期1381-1384,共4页
Sichuan Journal of Physiological Sciences
