摘要
目的探讨慢性支气管炎患者药物治疗前后T淋巴细胞亚群的变化与病症反复发作的相关性,为临床治疗提供判定依据。方法选择2020年4月1月至2021年4月30日新乡医学院第一附属医院收治的慢性支气管炎患者为研究对象,根据治疗后1年内复发次数是否≥2次,分为反复发作组和非反复发作组。比较两组治疗前后T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+))百分比,建立logistic回归分析不同时间点CD3^(+)、CD4^(+)、CD8^(+)与慢性支气管炎反复发作的关系,以Kaplan-Meier法绘制T淋巴细胞亚群的无复发曲线。结果共纳入患者162例,反复发作组95例(58.64%),非反复发作组67例(41.36%)。组内治疗前后比较显示,非反复发作组治疗10 d的CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+)上升,CD8^(+)下降(P<0.05);反复发作组治疗前后CD3^(+)、CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+)差异无统计学意义(P>0.05)。组间同时间点比较显示,反复发作组治疗5 d和治疗10 d的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)低于非反复发作组,而CD8^(+)高于非反复发作组(P<0.05)。logistic回归分析显示,治疗10 d的T淋巴细胞亚群是反复发作的独立影响因素,其中CD8^(+)升高是危险因素,CD3^(+)和CD4^(+)升高是其保护因素;而治疗前与治疗5 d的T淋巴细胞亚群与反复发作不相关。Kaplan-Meier分析显示,治疗10 d的CD3^(+)>58.73%且CD4^(+)>34.69%患者、CD8^(+)≤24.15%患者治疗后1年内的无复发情况较好(P<0.05)。结论慢性支气管炎治疗10 d的T淋巴细胞亚群与反复发作有相关性,CD3^(+)和CD4^(+)降低、CD8^(+)升高是反复发作的主要影响因素。
Objective To explore the asoociation between changes of T lymphocyte subsets before and after treatment and recurrence in patients with chronic bronchitis for providing criteria for clinical treatment.Methods Patients with chronic bronchitis treated in The First Afiliated Hospital of Xinxiang Medical University from 1 April 2020 to 30 April 2021,April 2021 were selected as study subjects.According to whether the number of recurrences within one year after treatment was≥2 times,they were divided into recurrent group and non-recurrent group.Compare the percentage of T lymphocyte subsets before and after treatment between the two groups.The logistic regression model was established to analyze the association between CD3t,CD4^(+)and CD8^(+)at different time points and recurrences of chronic bronchitis.Kaplan-Meier method was used to draw the nonrecurrent curve of T lymphocyte subsets.Results A total of 162 patients were included,with 95(58.64%)in the recurrent group and 67(41.36%)in the non-recurrent group.Compared with before treatment,CD3^(+)and CD4^(+)and CD4^(+)/CD8^(+)increased and CD8^(+)decreased in the non-recurrent group 10 days after treatment(P<0.05),and the difference of CD3^(+)、CD4、CD8^(+)and CD4^(+)/CD8^(+)between before treatment and afer treatment in the recurrent group was not statistically significant(P>0.05).Intergroup comparison showed that CD3^(+),CD4t,CD4^(+)/CD8^(+)in recurrent group were lower than those in non-recurrent group after treatment for 5 days and 10 days,while the CD8^(+)was higher than that in non-recurrent group(P<0.05).The logistic regression analysis showed that T lymphocyte subsets after treatment for 10 days were independent influencing factors of recurrence,among which the increase of CD8^(+)was a risk factor,and the increase of CD3^(+)and CD4^(+)was a protective factor.T lymphocyte subsets before and after treatment for 5 days were not associated with the recurrence.Kaplan-Meier analysis showed that patients with both CD3^(+)>58.73%and CD4^(+)>34.69%after treatment for
作者
贾睿岐
高远
张春晓
冯宪军
崔俊伟
JIA Ruiqi;GAO Yuan;ZHANG Chunxiao;FENG Xianjun;CUI Junwei(The First Affiliated Hospital,Xinxiang Medical University,Xinxiang,Henan 453100,China)
出处
《现代疾病预防控制》
2023年第7期512-517,共6页
MODERN DISEASE CONTROL AND PREVENTION
基金
河南省医学科技攻关计划联合共建(2018020344)
新乡医学院第一附属医院青年基金(QN-2019-A06)。
