摘要
目的探讨饮酒和乙醛脱氢酶2(ALDH2)基因rs671多态性对高血压的影响。方法选择2014—2016年在四川省人民医院健康管理中心进行了ALDH2基因检测的3465名健康体检者,根据高血压病史及血压测量值将其分为高血压组(n=768)和非高血压组(n=2697)。利用问卷调查收集研究对象的一般情况,包括饮酒史。采用DNA微阵列芯片法检测ALDH2基因型。应用多因素logistic回归模型分析饮酒和ALDH2与高血压患病风险的关联强度以及饮酒和ALDH2基因对高血压患病风险的相乘交互作用,利用Andersson编制的Excel表计算相加交互作用指标。结果ALDH2基因GG、GA和AA基因型分别占68.1%(2358/3465)、29.5%(1023/3465)和2.4%(84/3465),基因型分布符合Hardy-Weinberg平衡检验(χ^(2)=2.546,P>0.05)。高血压组饮酒比例高于非高血压组[34.0%(261/768)比27.6%(744/2697),χ^(2)=11.884,P=0.001],ALDH2基因GA/AA型占比低于非高血压组[25.4%(195/768)比33.8%(912/2697),χ^(2)=19.515,P<0.001]。多因素logistic回归分析显示,校正年龄、体质量指数、空腹血糖和吸烟史等因素后,男性ALDH2 GG基因型人群患高血压的风险是GA/AA型的1.396(95%CI 1.133~1.721)倍,男性饮酒者患高血压的风险是不饮酒者的1.351(95%CI 1.103~1.655)倍(均P<0.05)。未发现女性不同饮酒状态(OR=1.837,95%CI 0.003~1050.656)和基因型别(OR=1.318,95%CI 0.502~3.458)与高血压风险相关。多因素logistic回归分析发现,男性不饮酒+GG基因型组、饮酒+GG基因型组患高血压的风险分别是不饮酒+GA/AA基因型组的1.425倍(95%CI 1.127~1.802)和1.893倍(95%CI 1.465~2.447)(均P<0.05)。交互作用分析显示,未发现ALDH2基因多态性(rs671)和饮酒对男性高血压患病的相乘(P>0.05)和相加交互作用(相对超额危险度=0,95%CI-0.687~0.687)。结论ALDH2基因GG型和饮酒均为男性高血压的危险因素。暂未发现ALDH2基因rs671多态性和饮酒对高血压患病的相加或相乘交互作用。
Objective To explore the effect of alcohol consumption and aldehyde dehydrogenase 2(ALDH2)gene polymorphism(rs671)on hypertension.Methods A total of 3465 healthy physical examination participants who underwent ALDH2 gene testing at the health management and physical examination center of Sichuan Provincial People's Hospital from 2014 to 2016 were selected.They were divided into hypertension group(n=768)and nonhypertension group(n=2697)according to their history of hypertension and blood pressure measurement values.General information of the study subjects,including drinking history,was collected by questionnaire.ALDH2 genotype was determined by DNA microarray.Multivariate logistic regression analysis was used to analyze the association of alcohol consumption and ALDH2 genotype with the risk of hypertension and the interaction between alcohol consumption and ALDH2 gene polymorphism on the risk of hypertension.The additive interaction indicator was calculated using the Excel table compiled by AnderssonR.IesultsThe genotype frequencies for ALDH2 polymorphism was GG genotype 68.1%(2358/3465),GA genotype 29.5%(1023/3465),AA genotype 2.4%(84/3465),respectively,and the distribution of gene types was in accordance with Hardy-Weinberg equilibrium test(x2=2.546,P>0.05).The proportion of alcohol consumption in the hypertension group was higher than that in non-hypertension group[34.0%(261/768)us 27.6%(744/2697),χ^(2)=11.884,P=0.001],but the proportion of GA/AA gene type was lower[25.4%(195/768)us 33.8%(912/2697),χ^(2)=19.515,P<0.001].Multivariate logistic regression analysis showed that after adjusting for age,body mass index,fasting glucose and smoking history,the hypertension risk of male subjects with GG genotype was 1.396(95%CI 1.133-1.721)times higher than that of subjects with GA/AA genotype,the risk of male drinkers was 1.351(95%CI 1.103-1.655)times higher than that of non-drinkers(both P<o.05).No association was found between different drinking status(OR=-1.837,95%CI 0.003-1050.656),ALDH2 genotype(OR=1.318,95%CI 0
作者
侯钦钏
张芮
李炳宏
林禧龙
朱秀云
何霞
雍涛
杨亮亮
万政伟
刘玉萍
帅平
HOU Qinchuan;ZHANG Rui;LI Binghong;LIN Xilong;ZHU Xiuyun;HE Xia;YONG Tao;YANG Liangliang;WAN Zhengwei;LIU Yuping;SHUAI Ping(Department of Health Management&Physical Examination,Sichuan Provincial Peoples Hospital,University of Electronic Science and Technology of China,Chengdu,Sichuan 610072,China;School of Public Health,Southwest Medical University;School of Medicine,University of Electronic Science and Technology of China;Department of Health Management&Physical Eramination,Sichuan Province Panzhihua Central Hospital;Department of Pharmacy,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China)
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2023年第6期561-567,共7页
Chinese Journal of Hypertension
基金
四川省科技厅重点研发项目(2022YFS0600)
成都市科技局项目(2021-YF05-00498-SN)
四川省人民医院院基金项目(2021LY15)
四川省保健委员会2022年干部保健科研项目(川干研2022-220)。
关键词
高血压
乙醛脱氢酶2基因
饮酒
交互作用
hypertension
aldehyde dehydrogenase 2 gene
alcohol consumption
interaction
