摘要
目的观察中药菊荷方熏眼法治疗肝经郁热证干眼的临床疗效。方法纳入2022年1月—2022年10月中国中医科学院望京医院眼科诊治的肝经郁热证干眼患者90例(180只眼),随机分为中药熏眼组(A组)、温热熏蒸组(B组)、对照组(C组),每组各30例(60只眼)。A组予自拟菊荷方眼部熏蒸治疗,B组予注射用水加入熏眼器加热后眼部熏蒸治疗,C组予0.1%玻璃酸钠滴眼液治疗。3组均观察30 d。分别于治疗前、治疗后检测患者的眼表疾病指数量表(OSDI)积分、泪液分泌试验(SⅠT)、泪膜破裂时间(BUT)、中医证候积分的数据。结果3组治疗前的OSDI积分、SⅠT、BUT、中医证候积分比较,差异均无统计学意义。(1)OSDI积分:3组治疗后OSDI积分均较治疗前降低,差异有统计学意义(t_(A组)=17.752,t_(B组)=20.500,t_(C组)=18.551,均P=0.000)。治疗后3组间比较,差异有统计学意义(F=27.087,P=0.000)。与A组比较,B组和C组OSDI积分均较A组升高(t_(B组)=5.982,t_(C组)=6.711,均P=0.000),差异均有统计学义。(2)SⅠT:3组治疗后SⅠT均较治疗前增加,差异有统计学意义(t_(A组)=8.510,t_(B组)=4.370,t_(C组)=4.680,均P=0.000)。治疗后3组间比较,差异有统计学意义(F=34.442,P=0.000)。与A组比较,B组和C组SⅠT均降低,差异有统计学义(t_(B组)=6.548,t_(C组)=7.003,均P=0.000),B组和C组比较,差异无统计学义(P>0.05)。(3)BUT:3组治疗后BUT均较治疗前增加,差异有统计学意义(t_(A组)=21.031,t_(B组)=19.685,t_(C组)=7.746,均P=0.000)。治疗后3组间比较,差异有统计学意义(F=23.602,P=0.000)。与C组比较,A组、B组BUT均增加,差异有统计学义(t_(A组)=6.064,t_(B组)=5.493,均P=0.000),但A组和B组比较,差异无统计学义(P>0.05)。(4)中医证候积分:3组治疗后中医证候积分A组、B组较治疗前降低,差异有统计学意义(t_(A组)=21.465,P=0.000;t_(B组)=2.010,P=0.049)。C组治疗后中医证候积分差异无统计学意义(t_(C组)=0.938,P>0.05)。治疗后3组�
OBJECTIVE To observe the clinical efficacy of Traditional Chinese Medicine(TCM)Juhe Formula for liver Qi stagnation and heat syndrome in the treatment of dry eye.METHODS Ninety patients(180 eyes)diagnosed with liver Qi stagnation and heat syndrome-related dry eye,who received treatment at the Ophthalmology Department of Wangjing Hospital,China Academy of Chinese Medical Sciences,from January 2022 to October 2022,were randomly assigned into three groups:Chinese medicine fumigation group(Group A),warm steam fumigation group(Group B),and the control group(Group C),with 30 patients(60 eyes)in each group.Group A received self-formulated Juhe Formula,Group B received eye fumigation with heated water using an eye steamer,and Group C received 0.1%sodium hyaluronate eye drops.The patients were observed for 30 days.OSDI scores,SchirmerⅠtest(SⅠT),tear film break-up time(BUT),and TCM syndrome scores were measured before and after treatment.RESULTS There were no significant differences in OSDI scores,SⅠT,BUT,and TCM syndrome scores among the three groups before treatment.(1)OSDI scores:Compared with the pre-treatment scores,all three groups showed significant reductions in OSDI scores after treatment(t_(A)=17.752,t_(B)=20.500,t_(C)=18.551,all P=0.000).There were significant differences in post-treatment OSDI scores among the three groups(F=27.087,P=0.000).Group A had lower scores compared to Groups B and C(t_(B)=5.982,t_(C)=6.711,both P=0.000).(2)SⅠT:After treatment,SⅠT increased significantly in all three groups compared to pre-treatment values(t_(A)=8.510,t_(B)=4.370,t_(C)=4.680,all P=0.000).There were significant differences in post-treatment SⅠT among the three groups(F=34.442,P=0.000).Group A had higher values than Groups B and C(t_(B)=6.548,t_(C)=7.003,both P=0.000),while there was no significant difference between Groups B and C(P>0.05).(3)BUT:After treatment,BUT increased significantly in all three groups compared to pre-treatment values(t_(A)=21.031,t_(B)=19.685,t_(C)=7.746,all P=0.000).There were signifi
作者
李成武
周尚昆
刘静
包银兰
LI Chengwu;ZHOU Shangkun;LIU Jing;BAO Yinlan(Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China)
出处
《中国中医眼科杂志》
2023年第8期727-731,共5页
China Journal of Chinese Ophthalmology
基金
北京中医药“薪火传承3+3”工程唐由之名老中医工作站中国中医科学院望京医院分站建设项目
中国中医科学院望京医院科研课题(WJYY2020-25)。
关键词
菊荷方
熏眼法
干眼
Juhe Formula
fumigation therapy
dry eye syndrome
