摘要
目的分析血管内皮细胞生长因子C(VEGF⁃C)、细胞增殖指数Ki⁃67及张力蛋白同源物(PTEN)在皮肤恶性黑色素瘤患者中的表达及临床意义。方法收集2017年3月至2020年3月宣城市中心医院收治的59例皮肤恶性黑色素瘤患者作为研究组,另选同时期61例色素痣患者作为对照组。分析两组VEGF⁃C、Ki⁃67及PTEN的表达水平,分析VEGF⁃C、Ki⁃67及PTEN与皮肤恶性黑色素瘤病理特征及预后的关系。结果研究组VEGF⁃C、Ki⁃67阳性表达率均高于对照组,PTEN阳性表达率低于对照组,差异有统计学意义(P<0.05);临床分期Ⅲ~Ⅳ期、有淋巴结转移者VEGF⁃C、Ki⁃67阳性率明显高于临床分期Ⅰ~Ⅱ期、无淋巴结转移者,差异具有统计学意义(P<0.05)。临床分期Ⅰ~Ⅱ期、无淋巴结转移者PTEN阳性率明显高于临床分期Ⅲ~Ⅳ期、有淋巴结转移者,差异具有统计学意义(P<0.05)。术后对患者进行1年随访,死亡者12例(20.34%)。多元Logistic回归分析结果显示,临床分期Ⅲ~Ⅳ期、有淋巴结转移、VEGF⁃C及Ki⁃67阳性表达、PTEN阴性表达是影响皮肤恶性黑色素瘤患者预后死亡的独立危险因素(P<0.05)。结论在皮肤恶性黑色素瘤中VEGF⁃C、Ki⁃67阳性表达率高、PTEN阴性表达率高,推测VEGF⁃C、Ki⁃67及PTEN表达与皮肤恶性黑色素瘤疾病有着密切联系,三指标可作为评估皮肤恶性黑色素瘤病情进展及预后的有效检测指标。
Objective To analyze the expression and clinical significance of vascular endothelial growth factor C(VEGF⁃C),cell proliferation index Ki⁃67 and tensin homolog(PTEN)in patients with skin malignant melanoma.Methods 59 patients with skin malignant melanoma admitted to Xuancheng Central Hospital from March 2017 to March 2020 were collected as the study group,and 61 patients with pigmented nevus in the same period were selected as the control group.The expression of VEGF⁃C,Ki⁃67 and PTEN lev⁃elsbetween the two groups was analyzed,and the relationship between VEGF⁃C,Ki⁃67 and PTEN and the pathological features and prognosis of cutaneous malignant melanoma was analyzed.Results The positive ex⁃pression rates of VEGF⁃C and Ki⁃67 in the research group were higher than those in the control group,and the positive expression rate of PTEN was lower than that in the control group,the difference was statistically sig⁃nificant(P<0.05).The positive rates of VEGF⁃C and Ki⁃67 in patients with clinical stageⅢ~Ⅳand lymph node metastasis were significantly higher and the difference was statistically significant(P<0.05).The positive rate of PTEN in patients with clinical stageⅠ~Ⅱand no lymph node metastasis was significantly higher,the difference was statistically significant(P<0.05).The patients were followed up for 1 year after the operation,and 12 cases(20.34%)died.The results of multivariate logistic regression analysis showed that clinical stageⅢ~Ⅳ,lymph node metastasis,positive expression of VEGF⁃C and Ki⁃67,and negative expression of PTEN were independent risk factors affecting the prognosis and death of patients with cutaneous malignant melanoma(P<0.05).Conclusion In skin malignant melanoma,the positive expression rate of VEGF⁃C and Ki⁃67 is high,and the negative expression rate of PTEN is high.that the expression of VEGF⁃C,Ki⁃67 and PTEN are closely related to skin malignant melanoma,and can be used as effective indicators to evaluate the progression and prognosis of skin malig
作者
李杨
李启松
丁聪玲
王庆
LI Yang;LI Qisong;DING Congling;WANG Qing(Department of Pathology,Xuancheng Central Hospital,Xuancheng,Anhui,China,242000)
出处
《分子诊断与治疗杂志》
2023年第7期1252-1255,1260,共5页
Journal of Molecular Diagnostics and Therapy
基金
安徽省自然科学基金资助项目(1808185MH1035)。
