摘要
目的探讨血清碱性磷酸酶(ALP)联合全段甲状旁腺激素(iPTH)对血液透析(HD)患者主要不良心血管事件(MACE)的预测价值。方法选取2020年1月至2022年1月安徽省庐江县人民医院就诊的104例HD患者作为研究对象,并根据患者是否发生MACE将患者分为MACE组(n=37)和NMACE组(n=67)。比较两组一般资料和血清ALP和iPTH水平。多因素Logistic回归分析HD患者并发MACE的独立影响因素。受试者工作(ROC)曲线分析血清ALP和iPTH对HD患者并发MACE的预测价值。结果MACE组的病程、血磷、ALP均明显高于NMACE组,且血钙、iPTH水平明显低于NMACE组(t=3.526、2.373、24.126、10.558、13.524,P均<0.05)。多因素Logistic回归分析结果显示,病程、ALP、iPTH水平为HD患者并发MACE的独立危险因素(P<0.05)。ROC曲线结果显示,ALP、iPTH以及两者联合检测预测HD患者并发MACE的曲线下面积(AUC)为0.796、0.802、0.903,优于单一检测(P<0.05)。结论ALP、iPTH对HD患者MACE的发生具有一定的预测价值,且两者联合检测预测HD患者MACE的发生具有较高的价值,可以为临床评估HD患者发生MACE的风险提供参考。
Objective To investigate the predictive value of serum alkaline phosphatase(ALP)combined with total parathyroid hormone(iPTH)on major adverse cardiovascular events(MACE)in hemodi⁃alysis(HD)patients.Methods A total of 104 HD patients admitted to the People's Hospital of Lujiang Coun⁃ty,Anhui Province from January 2020 to January 2022 were selected as the study objects.According to the oc⁃currence of MACE,the patients were divided into the MACE group(n=37)and the NMACE group(n=67).The general data and serum ALP and iPTH levels were compared between the two groups.Multivariate logistic regression analysis was used to analyze the independent influencing factors of HD patients complicated with MACE.The predictive value of serum ALP and iPTH in HD patients with MACE was analyzed by ROC curve.Results The course of disease,blood phosphorus and ALP in the MACE group were significantly higher than those in the NMACE group,and the levels of blood calcium and iPTH were significantly lower than those in the NMACE group(t=3.526,2.373,24.126,10.558,13.524,P<0.05).Multivariate logistic regression analysis showed that the course of disease,ALP and iPTH levels were independent risk factors for HD patients with MACE(P<0.05).The ROC curve results showed that the area under the curve(AUC)predicted by ALP,iPTH and their combination for HD patients with MACE was 0.796,0.802 and 0.903.Conclusion ALP and iPTH have a certain predictive value for the occurrence of MACE in HD patients,and their combined detection has a high value in predicting the occurrence of MACE in HD patients,which can provide a reference for clinical assessment of the risk of MACE in HD patients.
作者
石柳平
许丽
陈玲
闫海
SHI Liuping;XU Li;CHEN Ling;YAN Hai(Hemodialysis Department,Lujiang County People’s Hospital,Lujiang,Anhui,China,231500)
出处
《分子诊断与治疗杂志》
2023年第7期1156-1159,共4页
Journal of Molecular Diagnostics and Therapy
基金
安徽省自然科学基金(2008085QH426)。
