摘要
目的研究高危型人乳头瘤病毒(HPV)阳性患者血清长链非编码RNA核仁小RNA宿主基因8(lncRNASNHG8)表达水平对宫颈癌的预测价值。方法纳入2019年1月至2021年12月郑州大学附属郑州中心医院收治的82例高危型HPV阳性宫颈癌患者为病例组,纳入因宫颈良性病变行手术切除的78例高危型HPV阳性患者作为对照组。检测两组血清lncRNA SNHG8表达水平及患者高危型HPV;采用多因素Logistic回归分析高危型HPV阳性患者发生宫颈癌的影响因素;绘制ROC曲线分析血清lncRNASNHG8表达水平对高危型HPV阳性患者发生宫颈癌的预测价值。结果病例组血清lncRNASNHG8表达水平及年龄≥50岁患者比例显著高于对照组,差异均有统计学意义(P<0.05)。lncRNASNHG8是高危型HPV阳性患者发生宫颈癌的独立危险因素(P<0.05)。血清lncRNASNHG8预测高危型HPV阳性患者发生宫颈癌的曲线下面积为0.835,敏感度为0.756,特异性为0.910。FIGO分期Ⅲ期+Ⅳ期、低分化、淋巴结转移的宫颈癌患者血清lncRNASNHG8表达水平显著高于FIGO分期Ⅰ期+Ⅱ期、中/高分化、无淋巴结转移的患者,差异均有统计学意义(P<0.05)。结论血清lncRNASNHG8表达水平与高危型HPV阳性患者发生宫颈癌有关。
Objective To study the predictive value of serum long non⁃coding RNA small nucleo⁃lar RNA host gene 8(lncRNA SNHG8)expression level for cervical cancer in high⁃risk human papillomavirus(HPV)positive patients.Methods Eighty⁃two high⁃risk HPV⁃positive cervical cancer patients were included as the case group,and 78 high⁃risk HPV⁃positive patients who underwent surgical resection for benign cervical lesions were included as the control group.The expression level of serum lncRNA SNHG8 and high⁃risk HPV was detected.The influencing factors were analyzed by multivariate Logistic regression analysis.The ROC curve was drawn to analyze the predictive value.Results The expression level of serum lncRNA SNHG8 and the proportion of patients aged≥50 years in the case group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).LncRNA SNHG8 was an independent risk factor for cervical cancer in high⁃risk HPV⁃positive patients(P<0.05).The area under the curve of serum lncRNA SN⁃HG8 for predicting cervical cancer in high⁃risk HPV⁃positive patients was 0.835,the sensitivity was 0.756,and the specificity was 0.910.The expression level of serum lncRNA SNHG8 in patients with FIGO stageⅢ+Ⅳ,poorly differentiated and lymph node metastasis was significantly higher than that in patients with FIGO stageⅠ+Ⅱ,moderately/well differentiated,and no lymph node metastasis,the difference was statistically significant(P<0.05).Conclusion The expression level of serum lncRNA SNHG8 is related to the occurrence of cervical cancer in high⁃risk HPV⁃positive patients.
作者
黄永杰
王桂珍
吕朋举
张春艳
HUANG Yongjie;WANG Guizhen;LV Pengju;ZHANG Chunyan(Department of Laboratory Medicine,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou,Henan,China,450007)
出处
《分子诊断与治疗杂志》
2023年第7期1099-1102,1107,共5页
Journal of Molecular Diagnostics and Therapy
基金
河南省医学科技攻关计划联合项目(LHGJ20191054)。
