摘要
Objective:To synthesize magnesium oxide nanoparticles using ethanol extract of shoots of Plicosepalus curviflorus(PC-MgONPs)and evaluate the antimicrobial,antioxidant,and anti-proliferative activities of PC-MgONPs.Methods:The green synthesized PC-MgONPs were characterized by ultraviolet-visible(UV),Fourier-transform infrared spectroscopy,zeta potential,energy dispersive X-ray,and scanning electron microscopy.Furthermore,we investigated total antioxidant capacity and antimicrobial and anti-proliferative activities using breast cancer cell lines(MDA-231).Results:The UV spectrum of PC-MgONPs showed a sharp absorption peak at 300 nm.The presence of magnesium,oxygen,and sodium was confirmed by energy dispersive X-ray analysis.Scanning electron microscopy revealed PC-MgONPs as roughly spherical granular structures with sizes ranging from 20.0 to 76.4nm.PC-MgONPs showed considerable antimicrobial activities against Escherichia coli,Staphylococcus aureus,methicillin-resistant Staphylococcus aureus,Pseudomonas aeruginosa and Candida albicans with zones of inhibition of 11-17 mm.In addition,total antioxidant capacity and anti-proliferative activity of PC-MgONPs against MDA-231 cells were dose-dependent.Conclusions:The synthesized PC-MgONPs could be a potent antimicrobial,antioxidant and anti-cancer agent,which needs further investigation.
基金
funded by the Researchers Supporting Project Number(RSPD2023R656)
King Saud University
Riyadh
Saudi Arabia。
