摘要
目的探讨术后第1天超敏C-反应蛋白/白蛋白比值(hs-CRP/ALB,HCAR)对结肠癌术后短期并发症风险的预测价值。方法回顾性分析2021年1月—2022年9月在湖州市中医院及湖州市中心医院住院行结肠癌根治手术的209例患者病历资料和实验数据,使用单变量和多变量分析用于确定术后并发症的危险因素。利用受试者工作特征曲线(ROC)分析HCAR对结肠癌术后短期并发症的预测价值。结果共有31例(14.8%)患者出现术后短期并发症,多变量logistic回归分析显示术后第1天HCAR是术后并发症的独立危险因素(OR=2.42,95%CI:1.45~4.79,P<0.01)。根据受试者工作特征曲线计算术后第1天HCAR的截断值为0.96,曲线下面积(AUC)、敏感度、特异度分别为0.933、0.813、0.859。与HCAR<0.96的患者比较,HCAR>0.96的患者术后并发症的发生率更高(23.6%vs 8.3%),术后住院时间更长(13.6 d±4.2 d vs 11.0 d±0.9 d),差异均有统计学意义(P<0.01)。结论术后第1天HCAR>0.96的患者更有可能发生术后短期并发症,术后第1天HCAR可作为预测结肠癌术后短期并发症风险的有效指标。
Objective This paper aims to investigate the predictive value of high-sensitivity C-reactive protein/albumin ratio(hs-CRP/ALB,HCAR)on the first postoperative day(POD1)to the risk of short-term complications after colon cancer surgery.Methods The clinical information and laboratory data of 209 patients who underwent radical resection of colon cancer in Huzhou Hospital of Traditional Chinese Medicine and Huzhou Central Hospital from January 2021 to September 2022 were analyzed retrospectively.Univariate and multivariate analyses were used to determine the risk factors for postoperative complica⁃tions.The receiver operating characteristic curve(ROC)was used to analyze the predictive value of HCAR for short-term complications after colon cancer surgery.Results A total of 31 patients(14.8%)had postoperative short-term complica⁃tions.Multivariate logistic regression analysis showed that HCAR on POD1 was an independent risk factor for postoperative com⁃plications(OR=2.42,95%CI:1.45-4.79,P<0.01).The cutoff value of HCAR on POD1 was 0.96 by receiver operating characteristic curves(ROC).The area under the curve(AUC),sensitivity and specificity were 0.933,0.813 and 0.859,respectively.Compared with patients with HCAR<0.96,patients with HCAR>0.96 had higher incidence of postoperative complications(23.6%vs 8.3%)and longer postoperative hospital stay(13.6 d±4.2 d vs 11.0 d±0.9 d),and the differences were statistically significant(P<0.01).Conclusion Patients with HCAR greater than 0.96 on POD1 are more likely to have postoperative complications.HCAR on POD1 can be used as an effective indicator to predict the risk of short-term postoperative complications in colon cancer.
作者
何君君
HE Jun-jun(Department of Clinical Laboratory,Huzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University,Huzhou,Zhejiang 313000,China)
出处
《中国卫生检验杂志》
CAS
2023年第13期1609-1612,共4页
Chinese Journal of Health Laboratory Technology
关键词
结肠癌
并发症
超敏C-反应蛋白
白蛋白
超敏C-反应蛋白/白蛋白比值
Colon cancer
Complication
High-sensitivity C-reactive protein
Albumin
High-sensitivity C-reactive pro⁃tein to albumin ratio
