摘要
目的探讨表观扩散系数最小值(apparent diffusion coefficient minimum,ADCmin)在鉴别外周带早期前列腺癌(prostate cancer,PCa)与慢性前列腺炎中的诊断价值。材料与方法回顾性分析经病理学证实的65例早期PCa与39例慢性前列腺炎的MRI资料,病灶均位于前列腺外周带,测量病灶实质的ADC平均值(mean apparent diffusion coefficient,ADCmean)和ADCmin,对两组患者的ADCmean和ADCmin进行差异性分析。采用受试者工作特征(receiver operating characteristic,ROC)曲线和DeLong检验进行评价和比较ADCmean和ADCmin对外周带早期PCa与慢性前列腺炎的诊断效能。结果早期PCa组ADCmean和ADCmin均小于慢性前列腺炎组,组间差异均有统计学意义(P<0.001)。ADCmean和ADCmin的ROC曲线下面积(area under the curve,AUC)分别为0.888和0.935,使用DeLong检验比较两者的诊断效能差异有统计学意义(P<0.05)。ADCmean最佳截断值为1.008×10-3mm2/s,诊断早期PCa的敏感度和特异度分别为81.54%、94.87%;ADCmin最佳截断值为0.861×10-3mm2/s,诊断早期PCa的敏感度和特异度分别为83.08%、94.87%。结论ADCmin鉴别外周带早期PCa与慢性前列腺炎的诊断效能优于ADCmean,具有较好的临床参考价值。
Objective:To explore the value of apparent diffusion coefficient minimum(ADCmin)in differential diagnosis of early prostate cancer(PCa)and chronic prostatitis in peripheral zone.Materials and Methods:The MRI data of 65 patients of early PCa and 39 patients of chronic prostatitis with pathology confiemed were retrospectively analyzed,the lesions were all located in the peripheral zone of prostate,the mean apparent diffusion coefficient(ADCmean)and ADCmin of the parenchyma of the lesion were measured,the difference of ADCmean and ADCmin between the two groups were analyzed.The receiver operating characteristic(ROC)curve and DeLong test were used to evaluate and compare the diagnostic efficiency of ADCmean and ADCmin for early PCa and chronic prostatitis in peripheral zone.Results:The ADCmean and ADCmin in the early PCa group were lower than those in the chronic prostatitis group,and differences between groups were statistically significant(P<0.001).The area under the curve(AUC)of ADCmean and ADCmin were 0.888 and 0.935,there was statistical difference in diagnostic performance by DeLong test(P<0.05).The optimal cut-off value of ADCmean was 1.008×10-3 mm2/s,the sensitivity and specificity or the diagnosis of early PCa were 81.54%,94.87%,respectively.The optimal cut-off value of ADCmin was 0.861×10-3 mm2/s,the sensitivity and specificity for the diagnosis of early PCa were 83.08%,94.87%,respectively.Conclusions:The diagnostic efficacy of ADCmin in differentiating early PCa and chronic prostatitis in the peripheral zone is better than that of ADCmean,which has good clinical reference value.
作者
方磊
方慧
金利
刘新疆
FANG Lei;FANG Hui;JIN Li;LIU Xinjiang(Department of Radiology,Pudong Hospital,Fudan University,Shanghai 201399,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2023年第7期93-97,共5页
Chinese Journal of Magnetic Resonance Imaging
基金
上海市卫健委卫生行业临床研究专项(编号:202140266)
上海市浦东新区卫生系统学科建设项目(编号:PWZbr2022-16)。
关键词
前列腺肿瘤
前列腺癌
慢性前列腺炎
磁共振成像
表观扩散系数
prostatic neoplasms
prostate cancer
chronic prostatitis
magnetic resonance imaging
apparent diffusion coefficient
