摘要
目的:分析新型冠状病毒感染(COVID-19)后发生新冠肺炎的危险因素,增强对新型冠状病毒肺炎疾病的认知,为其临床诊治与预防提供临床依据。方法:纳入内蒙古自治区某新冠肺炎指定治疗医院399例COVID-19患者,回顾分析奥秘克戎病毒引起的新冠肺炎的特征与危险因素;采用单因素分析、二元Logistic回归分析探究新型冠状病毒感染后发生新冠肺炎的危险因素。结果:两组患者在年龄、基础疾病史、实验室检查以及临床症状上均有显著性差异;单因素分析显示两组患者的年龄、糖尿病、类风湿关节炎、白蛋白、白蛋白/球蛋白、IL-6、C反应蛋白差异有显著意义;二元Logistic回归分析显示C反应蛋白、内分泌疾病史以及ORF1ab基因的CT值可能为发生新冠肺炎的危险因素;白蛋白则为保护因素。结论:年龄、基础疾病史以及C反应蛋白/IL-6升高,均会导致COVID-19患者发生新冠肺炎,应根据疾病的影响因素进一步开展针对性的预防干预措施。
Objective:To analyze the risk factors associated with the development of COVID-19 and enhance the understanding of its disease progression,providing a clinical basis for diagnosis,treatment,and prevention of severe diseases.Methods:A retrospective analysis of 399 patients with COVID-19 was conducted at a designated hospital for COVID-19 treatment in Inner Mongolia Autonomous Region,focusing on the characteristics and risk factors associated with the development of COVID-19.Univariate and binary logistic regression analyses were used to explore the risk factors for novel coronavirus infection.Results:There were significant differences in age,underlying disease history,laboratory examination,and clinical symptoms between the two groups.Univariate analysis showed significant differences in age,diabetes,rheumatoid arthritis,albumin concentration,albumin/globulin ratio,and IL-6 and C-reactive protein levels between the two groups.Binary Logistic regression analysis showed that C-reactive protein level,endocrine disease history,and ORF1ab gene CT value may be risk factors for COVID-19,whereas albumin level may be a protective factor.Conclusion:Age,underlying disease history,and elevated C-reactive protein/IL-6 levels are contributing factors to the development of COVID-19.Further targeted preventive interventions should consider the risk factors of the disease.
作者
李婧娥
王芙蓉
柴军
姚丽丽
田广原
高笑宇
孙德俊
LI Jing’e;WANG Furong;CHAI Jun;YAO Lili;TIAN Guangyuan;GAO Xiaoyu;SUN Dejun(Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014000,China;Key Laboratory of COPD Diagnosis and Treatment of National Health Commission,Inner Mongolia Autonomous Region People's Hospital/Inner Mongolia Key Laboratory of Respiratory Diseases,Hohhot 010017,China;Department of Respiratory and Critical Care Medicine,Inner Mongolia People's Hospital,Hohhot 010017,China;Department of Imaging Medicine,Inner Mongolia People's Hospital,Hohhot 010017,China;The Fourth Hospital of Inner Mongolia Autonomous Region,Hohhot 010017,China)
出处
《CT理论与应用研究（中英文）》
2023年第3期419-427,共9页
Computerized Tomography Theory and Applications
基金
内蒙古自治区科技计划项目(内蒙古自治区呼吸疾病重点实验室(内财科[2022]1405号
内财科[2022]662号))
国家自然科学基金地区项目(MRP4在慢性阻塞性肺疾病中的作用和机制研究(81960013))
中央引导地方科技发展资金项目(烟碱乙酰胆碱受体a3通过CACNA1F/IP3/IPR3/Ca2+途径调控气道上皮细胞增殖促进慢阻肺发生的研究(ZYZ20200486))
内蒙古自然科学基金面上项目(罗斯氏菌通过丁酸介导的HDACI/STATA1/AP1/NLRP3信号途径预防哮喘发生(2021MS08165))。
