摘要
目的 基于数据挖掘分析王靖教授治疗慢性心力衰竭(CHF)的用药规律。方法 选取2018年1月至2020年6月就诊于江苏省泰州市中医院王靖教授门诊的124例CHF患者为研究对象,对医案中的数据进行整理,统计患者症状、脉象及中医证型。采用频次分布、聚类分析、关联规则分析、复杂网络分析方法对医案中高频使用药物、药物属性分布(四气、五味、归经、功效)、核心药物及组合进行分析。结果 124例患者症状以胸闷、气短、乏力多见,证型主要为气虚血瘀兼阳虚证,脉象主要为脉沉弦细。本研究共纳入638例处方,涉及175味药物,药物使用总频次1 700次。其中以补虚药、活血化瘀药、利水渗湿药多见,四气以温、寒、平居多,五味以甘、苦为主,多归脾、肺、肝经。出现频率≥20次的药物共27种,聚类分析可将其分为3类。关联分析得到药物关联规则23条,复杂网络分析发现黄芪、当归、川芎、红景天等为治疗CHF的核心药物。结论 王靖教授治疗CHF以补虚为本,用药以补虚药、活血化瘀药、利水渗湿药为主。
Objective To analyze the medication rules of Professor Wang Jing in the treatment of chronic heart failure(CHF)based on data mining.Methods A total of 124 patients with CHF admitted to Professor Wang Jing’s clinic in Taizhou Hospital of Traditional Chinese Medicine of Jiangsu Province from January 2018 to June 2020 were selected as the research objects.The data in the medical records were sorted out and the symptoms,pulse signs,and traditional Chinese medicine syndrome types of the patients were counted.The methods of frequency distribution,cluster analysis,association rule analysis,and complex network analysis were used to analyze the drugs frequently,drug attribute distribution(four nature,five flavours,channel tropism,and efficacy),core drugs,and their combinations used in medical records.Results The most common symptoms of the 124 patients were oppression in chest,panting,and weakness.The main syndrome type was blood stasis due to qi deficiency combined with yang deficiency,and the main pulse pattern was deep,stringy,thready pulse.A total of 638 prescriptions were included in this study,involving 175 drugs,and the total frequency of drug use was 1700 times.Among them,tonifying deficiency drugs,promoting blood circulation for removing blood stasis drugs,diuresis and diffusing dampness drugs were common.The four natures were mainly warm,cold,and flat,and the five flavours were mainly sweet and bitter,mostly returning to the spleen,lung,and liver channels.There were 27 drugs with frequency≥20 times,which could be divided into three categories by cluster analysis.Twenty-three drug association rules were obtained by association analysis.Complex network analysis found that Astragali Radix,Angelicae Sinensis Radix,Chuanxiong Rhizoma,Rhodiolae Crenulatae Radix Et Rhizoma and so on were the core drugs for the treatment of CHF.Conclusion Professor Wang Jing’s treatment of CHF is based on tonifying deficiency,and drugs mainly include tonifying deficiency,promoting blood circulation for removing blood stasis,and di
作者
缪文雄
单亚娟
陈旸
王靖
MIAO Wenxiong;SHAN Yajuan;CHEN Yang;WANG Jing(Department of Internal Traditional Chinese Medicine,Taizhou Hospital of Traditional Chinese Medicine,Jiangsu Province,Taizhou225300,China)
出处
《中国医药导报》
CAS
2023年第20期23-28,共6页
China Medical Herald
基金
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号)。
关键词
数据挖掘
王靖
慢性心力衰竭
经验
Data mining
Wang Jing
Chronic heart failure
Experience
