摘要
目的:探讨胸腔镜肺癌根治术患者血清锌含量与炎症发生及肿瘤相关巨噬细胞M1极化的相关性。方法:132例行胸腔镜下肺癌根治术患者入组(70例鳞癌和62例腺癌),在术前采用原子吸收分光光度法检测血清锌含量;在术前、术后即刻和术后6 h采集患者血样并进行血清高敏C-反应蛋白(hs-CRP)检测及血清过氧化氢酶检测。对切除的肺癌组织中巨噬细胞M1极化(促炎极化)因子进行测定分析。将患者分为高血清锌组(高锌组,67例)和低血清锌组(低锌组,65例)。统计患者血清锌含量与临床表征、围手术期hs-CRP、过氧化氢酶以及肺癌组织中巨噬细胞M1极化因子表达的相关性。计量统计应用 t检验或 Mann- Whitney检验,计数统计应用 χ^(2)检验。 结果:行胸腔镜下肺癌根治术患者高血清锌组与低血清锌组相比,术前hs-CRP[(1.69±0.66)mg/L对(1.99±0.43)mg/L]和术后6 h hs-CRP[(3.51±1.01)mg/L对(4.59±0.78)mg/L]均低,组间差异有统计学意义。结论:行胸腔镜下肺癌根治术患者血清锌含量与炎症发生及肿瘤相关巨噬细胞M1极化存在负性相关性,提示适当补锌对胸腔镜下肺癌根治术患者具有保护作用。
ObjectiveTo explore the molecular mechanism of zinc donor regulating macrophage polarization,and to explore the correlation between serum zinc content and the clinical index during radical resection of lung cancer.MethodsOne hundred and thirty-two patients who undergoing radical resection of lung cancer were enrolled in this study.The serum zinc content was detected by atomic absorption spectrophotometry before operation.The patients were allocated into high-Zn group and low-Zn group.The blood samples of the included subjects were collected before operation(before),immediately after operation(POP1)and 6 hours after operation(POP2),and the plasma high-sensitivity C-reactive protein(hs-CRP)and catalase were detected.The correlation between serum zinc content and clinical features were analyzed.Metrological statistics was performed by using t test or Mann-Whitney test,and counting statistics was performed by χ^(2) test.ResultsThe POP1-hs-CRP[(1.69±0.66)mg/L vs.(1.99±0.43)mg/L],POP2-hs-CRP[(3.51±1.01)mg/L vs.(4.59±0.78)mg/L]and other indicators of high-Zn group were significantly lower than those of low-Zn group.ConclusionThere is a negative correlation between serum zinc content and the inflammation during radical resection of lung cancer,suggesting that appropriate zinc supplementation has a protective effect on radical resection of lung cancer patients.
作者
陈雯辉
魏博
Chen Wenhui;Wei Bo(Department of Thoracic Surgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)
出处
《中华胸心血管外科杂志》
CSCD
北大核心
2023年第6期348-351,共4页
Chinese Journal of Thoracic and Cardiovascular Surgery
关键词
胸腔镜下肺癌根治术
炎性因子
血清锌含量
巨噬细胞
Radical resection of lung cancer
Inflammatory factor
Serum zinc content
Macrophage
