摘要
目的应用超脉冲打孔预处理联合光动力疗法治疗增生性瘢痕,并对其疗效进行分析。方法选择2019年12月至2021年4月广东省汕头市皮肤医院门诊收治的60例患者,其中男性39例,女性21例;年龄23~51岁,平均年龄33.7岁;皮损部位,胸背部39例,肩胛部13例,上肢5例,下腹部3例。根据治疗方式分为治疗组30例和对照组30例。治疗组采用超脉冲打孔预处理联合光动力疗法治疗,对照组采用糖皮质激素皮内注射治疗。比较两组的瘢痕评分、临床有效率、不良反应率、复发率及患者的满意率。结果两组治疗前温哥华瘢痕量表评分比较(15.6分±3.5分vs 15.4分±3.2分),差异无统计学意义(P>0.05);治疗组治疗后1、3、6、12个月评分均低于对照组,其中3、6、12个月评分比较(3个月:7.9分±1.7分vs 9.5分±2.2分;6个月:5.4分±1.4分vs 7.3分±1.6分;12个月:2.8分±1.0分vs 4.6分±2.4分),差异有显著统计学意义(P<0.01)。治疗组患者的临床治疗有效率高于对照组(96.7%vs 73.3%),差异有统计学意义(P<0.05)。治疗组患者对于治疗效果的满意率高于对照组(96.7%vs 63.3%),差异有统计学意义(P<0.05)。随访12个月结果,治疗组有1例出现瘢痕组织增生,复发率3.3%;对照组患者有5例出现瘢痕复发,复发率16.7%;治疗组复发率低于对照组,但差异无统计学意义(P>0.05)。治疗组患者不良反应率3.3%;对照组患者不良反应率30.0%,治疗组不良反应率低于对照组,差异有统计学意义(P<0.05)。结论超脉冲激光打孔预处理联合光动力治疗增生性瘢痕疗效显著,患者满意度高。
Objective To analyze the curative effect ultra-pulse drilling pretreatment combined with photodynamic therapy in treatment of hyperplastic scar.Methods From December 2019 to April 2021,a total of 60 patients in clinic were enrolled,which included 39 males and 21 females,aged 23-51 years old with mean age of 33.7 years old.The lesions were located at dorsal part of chest in 39 cases,scapula in 13,upper limbs in 5 and lower abdomen in 3.According to treatment method,all of them were divided into treatment group(n=30)and control group(n=30).The treatment group performed ultra-pulse drilling pretreatment combined with photodynamic therapy,while control group was treated with intracutaneous injection of glucocorticoid.The scar score,clinical effective rate,adverse reaction rate,recurrence rate and patient satisfaction rate between 2 groups were compared.Results There was no significant difference in Vancouver Scar Scale score before treatment between 2 groups(15.6 scores±3.5 scores vs 15.4 scores±3.2 scores.P>0.05).The scores of treatment group at 1-month,3-month,6-month and 12-month after treatment were lower than those of control group,and there were significant differences in scores at 3-month,6-month and 12-month post treatment between 2 groups(3-month:7.9 scores±1.7 scores vs 9.5 scores±2.2 scores;6-month:5.4 scores±1.4 scores us 7.3 scores±1.6 scores;12-month:2.8 scores±1.0 scores vs 4.6 scores±2.4 scores.P<0.01).The effective rate of treatment group was statistically significantly higher than that of control group(96.7%vs 73.3%.P<0.05).The satisfaction rate of treatment group was statistically significantly higher than control group(96.7%vs 63.3%,P<0.05).After 12-month follow-up,there was 1 case of scar tissue hyperplasia in treatment group,and recurrence rate was 3.3%.In control group,scar recurrence occurred in 5 cases,and recurrence rate of 16.7%.The recurrence rate of treatment group was lower than control group,and there was not statistically significant difference(P>0.05).The adverse reaction rate
作者
杨易
王焕斌
徐莺
YANG Yi;WANG Huan-bin;XU Ying(Department of Dermatology,Guangdong Shantou Dermatological Hospital,Shantou 515000,Guangdong,China)
出处
《生物医学工程与临床》
CAS
2023年第3期342-345,共4页
Biomedical Engineering and Clinical Medicine
基金
2020年汕头市医疗卫生科技计划项目(200710095260158)。
关键词
超脉冲
光动力
增生性瘢痕
预处理
super pulse
photodynamic force
hypertrophic scar
pretreatment
