摘要
为进行熊去氧胆酸原料药的质量控制,合成了7个有关物质。分别以鹅去氧胆酸、猪去氧胆酸、石胆酸为原料,经氧化、酯化、酰化、还原等步骤,分别制得有关物质3,7-二氧代胆烷酸、7α-羟基-3-氧代胆烷酸、7-氧代石胆酸、3-羟基-6-氧代胆烷酸、3,6-二氧代胆烷酸、3-氧代胆烷酸、3β,7α-二羟基胆烷酸,收率分别为68%、17%、74%、60%、76%、70%、15%。上述有关物质的化学结构经NMR和HRMS确证。
In order to perform the quality control of ursodeoxycholic acid,seven related substances were synthesized.3,7-Dioxocholanoic acid,7α-hydroxy-3-oxocholanoic acid,7-oxolithocholic acid,3-hydroxy-6-oxocholanoic acid,3,6-dioxocholanoic acid,3-oxocholanoic acid and 3β,7α-dihydroxycholanoic acid were synthesized from chenodeoxycholic acid,hyodeoxycholic acid,or lithocholic acid via oxidation,esterification,acylation and reduction.The yields were 68%,17%,74%,60%,76%,70%and 15%,respectively.The chemical structures of above related substances were confirmed by NMR and HRMS.
作者
张倚鸣
冉启军
程铖
汤磊
王建塔
朱高峰
ZHANG Yiming;RAN Qijun;CHENG Cheng;TANG Lei;WANG Jianta;ZHU Gaofeng(School of Pharmacy,Guizhou Medical University,Guiyang 550004;Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D,Guiyang 550004;Guizhou Public Resource Trading Center,Guiyang 550002)
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2023年第4期533-539,共7页
Chinese Journal of Pharmaceuticals
基金
贵州省普通高等学校科技拔尖人才支持计划项目(黔教合KY字[2017]072)
贵州省卫生健康委科学技术基金项目(gzwkj2022-469)
贵州省科技计划项目黔科合支撑[2020]4Y234。
关键词
熊去氧胆酸
有关物质
合成
ursodeoxycholic acid
related substance
synthesis
