摘要
目的探讨黄连阿胶鸡子黄汤加减治疗阴虚型失眠的临床效果及对睡眠状态的影响。方法选取2020年1月至2022年1月我院收治的90例阴虚型失眠患者作为研究对象,根据治疗方案不同将其分为对照组和观察组,每组45例。对照组采用常规治疗,观察组在常规治疗基础上予以黄连阿胶鸡子黄汤加减治疗。比较两组的治疗效果。结果观察组的治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的匹兹堡睡眠质量指数(PSQI)量表各维度评分低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的觉醒次数少于对照组,深睡眠时间、快速动眼(REM)时间均长于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的5-羟色胺(5-HT)、前列腺素D_(2)(PGD_(2))水平均高于对照组,差异具有统计学意义(P<0.05)。结论黄连阿胶鸡子黄汤加减在阴虚型失眠中的应用效果显著,有助于改善患者的睡眠状态,也能调节5-HT、PGD_(2)水平。
Objective To explore the clinical effect of modified Huanglian Ejiao Jizihuang decoction in insomnia of Yin deficiency type and its influence on sleep state.Methods A total of 90 patients with insomnia of Yin deficiency type admitted in our hospital from January 2020 to January 2022 were selected as the research objects and divided into control group and observation group according to different treatment plan,with 45 cases in each group.The control group was treated with routine treatment,and the observation group was treated with modified Huanglian Ejiao Jizihuang decoction on the basis of routine treatment.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of each dimension of the Pittsburgh Sleep Quality Index(PSQI)scale in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the number of awakenings in the observation group was less than that in the control group,the deep sleep time and rapid eye movement(REM)time were longer than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of 5-hydroxytryptamine(5-HT)and prostaglandin D_(2)(PGD_(2))in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The modified Huanglian Ejiao Jizihuang decoction in insomnia of Yin deficiency type has a significant application effect,which helps to improve the sleep state of patients,and also regulate the levels of 5-HT and PGD_(2).
作者
张瑞
李琳
ZHANG Rui;LI Lin(Traditional Chinese Medicine Hospital of Baoji,Baoji 721001,China)
出处
《临床医学研究与实践》
2023年第21期105-108,共4页
Clinical Research and Practice
基金
宝鸡市卫生健康委员会科研课题(No.2020-035)。
关键词
黄连阿胶鸡子黄汤
阴虚型失眠
5-羟色胺
前列腺素D2
睡眠状态
Huanglian Ejiao Jizihuang decoction
insomnia of Yin deficiency type
5-hydroxytryptamine
prostaglandin D2
sleep state
