摘要
目的:探讨名老中医治疗腹泻的用药经验和规律。方法:以名医传承平台为数据源,按照西医病名“腹泻”对自建库以来所有相关病例进行搜索,通过数据挖掘软件对筛选后的方剂进行频次统计分析、关联规则分析、系统聚类、因子分析以及复杂网络拓扑结构分析。结果:检索到131首方剂,177味中药,主要以补虚药、清热药、解表药、理气药、利水渗湿药和收涩药为主。药物四气以温性为主,五味以辛、甘、苦为主,主要归肝经、肺经、脾经和胃经。关联规则分析发现104项,其中为4味药物的规则有37项。因子分析可提取的公因子数有9个,系统聚类得出7大类。基础方剂主要有四君子汤、参苓白术散、芍药甘草汤、左金丸、半夏泻心汤、葛根芩连汤、二神丸等。复杂网络分析得出核心药物是白术、甘草、白芍、茯苓、陈皮、党参、薏苡仁。结论:名老中医治疗腹泻遵循《黄帝内经》相关理论,以祛湿、升阳和固本止泻为基本原则,但对小肠尚未引起足够的重视,有待后续研究。
Objective:To explore the medication experience and rules of prestigious veteran traditional Chinese medicine(TCM)doctors in treating diarrhea.Methods:Traditional Chinese Medicine Inheritance Support System(TCMISS)was used as the data source.All relevant cases since inception of the platform were searched using the western medical term“diarrhea”.Data mining software was used for frequency statistical analysis,association rule analysis,systematic clustering,factor analysis,and complex network topology analysis of the selected prescriptions.Results:A total of 131 prescriptions and 177 drugs were retrieved.The prescriptions mainly consisted of deficiency-tonifying drugs,heat-clearing drugs,exterior-releasing drugs,qi-regulating drugs,urination-promoting and dampness-draining drugs,and astringent drugs.The drugs were mainly warm,pungent,sweet,and bitter,and acted on the liver meridian,lung meridian,spleen meridian,and stomach meridian.Association rule analysis revealed 104 rules,with 37 rules involving four drugs.Factor analysis identified nine common factors,and systematic clustering resulted in seven major categories.Foundational prescriptions included Sijunzi Decoction,Shenling Baizhu Powder,Shaoyao Gancao Decoction,Zuojin Pills,Banxia Xiexin Decoction,Gegen Qinlian Decoction,and Ershen Pills.Complex network analysis identified key drugs,such as Atractylodis Macrocephalae Rhizoma,Glycyrrhizae Radix Et Rhizoma,Paeoniae Radix Alba,Poria,Citri Reticulatae Pericarpium,Codonopsis Radix,and Coicis Semen.Conclusion:Prestigious veteran TCM doctors follow the theories in the Huangdi′s Internal Classic(Huang Di Nei Jing)when treating diarrhea,emphasizing the principles of eliminating dampness,warming yang,and consolidating root to check diarrhea.However,the attention given to the small intestine is not sufficient and requires further research.
作者
赵浩斌
翟双庆
ZHAO Haobin;ZHAI Shuangqing(School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《世界中医药》
CAS
2023年第11期1601-1608,共8页
World Chinese Medicine
基金
国家重点研发计划项目(2018YFC1704100)——东北部地区名老中医学术观点、特色诊疗方法和重大疾病防治经验研究(2018YFC1704105)。
关键词
《黄帝内经》
名老中医
腹泻
数据挖掘
用药规律
复杂网络
因子分析
聚类分析
关联规则
Huangdi′s Internal Classic
Prestigious veteran TCM doctors
Diarrhea
Data mining
Medication rule
Complex network
Factor analysis
Clustering analysis
Association rules
