摘要
急性肝衰竭是肝脏疾病中最为凶险的类型之一,发病急、病情重、死亡率高。在临床治疗中主要以肝脏移植为主,缺乏其他有效的治疗手段。而肠道微生物是人体内十分独特的组成部分,它通过“肝-肠轴”对肝脏疾病的发生发展发挥作用。在肝衰竭的治疗中对肠道菌群研究获得了广泛的关注,通过肠道内微生物移植缓解急性肝衰竭成为研究热点。本文将针对微生物移植在急性肝衰竭治疗中的研究进展作一综述。
Acute liver failure is one of the most dangerous types of liver diseases,with acute onset,severe disease and high mortality.Liver transplantation is the mainstay of clinical treatment,and other effective treatments are lacking.The gut microbiota is a very unique part of the human body,and it plays a role in the occurrence and development of liver diseases through the″liver-gut axis″.In the treatment of liver failure,the study of gut microbiota has gained extensive attention,and the alleviation of acute liver failure by intestinal microbial transplantation has become a research hotspot.This article discussed the research progress of microbial transplantation in the treatment of acute liver failure.
作者
刘淑慧
胡建华
LIU Shuhui;HU Jianhua(Department of Integrative Chinese and Western Medicine,Beijing You′an Hospital,Capital Medical University,Beijing 100069,China)
出处
《胃肠病学和肝病学杂志》
CAS
2023年第7期829-832,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
北京市扬帆计划重点医学专业-中西医结合重症肝病(ZYLX201819)
中西医结合防治传染病临床与基础研究-中西医专项课题(BJYY-YN2022-32)。
关键词
肠道菌群
微生物移植
急性肝衰竭
研究进展
Intestinal flora
Microbial transplantation
Acute liver failure
Research progress
