摘要
【目的】探讨肝癌衍生生长因子(HDGF)、血管内皮生长因子(VEGF)表达与肝癌患者病灶浸润转移风险的相关性。【方法】回顾性分析2019年7月至2022年7月西安市第三医院西北大学附属医院收治的82例接受手术切除治疗的肝癌患者的临床资料,收集患者的肝癌组织标本和癌旁组织。采用免疫组化染色法检测肝癌组织及癌旁组织内HDGF、VEGF表达情况,比较不同临床病理特征肝癌患者HDGF、VEGF表达水平,采用多因素logistic回归分析影响肝癌组织HDGF、VEGF表达的危险因素。【结果】肝癌组织中HDGF、VEGF阳性表达率高于癌旁组织,差异有统计学意义(P<0.05)。不同AJCC分期、包膜完整性和肿瘤转移的肝癌组织HDGF、VEGF表达比较,差异有统计学意义(P<0.05)。多因素Logistic回归模型分析显示,AJCC分期、包膜完整性和肿瘤转移是肝癌组织HDGF、VEGF表达的影响因素(P<0.05)。【结论】肝癌组织中HDGF、VEGF呈高表达,且与AJCC分期、包膜完整性和肿瘤转移相关,对评估肝癌进展有一定的参考价值。
【Objective】To investigate the correlation between the expression of hepatoma derived growth factor(HDGF),Vascular endothelial growth factor(VEGF)and the risk of invasion and metastasis of liver cancer.【Methods】A retrospective analysis was conducted on the clinical data of 82 liver cancer patients who underwent surgical resection treatment at the Northwest University Affiliated Hospital of Xi'an Third Hospital from July 2019 to July 2022.Liver cancer tissue samples and adjacent tissues were collected from the patients.Immunohistochemical staining was used to detect the expression of HDGF and VEGF in liver cancer tissue and adjacent tissues,and to compare the expression of HDGF and VEGF in liver cancer patients with different clinical and pathological characteristics.Multivariate logistic regression analysis was used to analyze the risk factors affecting the expression of HDGF and VEGF in liver cancer tissue.【Results】The positive expression rates of HDGF and VEGF in liver cancer tissues were higher than those in adjacent tissues,and the difference was statistically significant(P<0.05).There was a statistically significant difference in the expression of HDGF and VEGF in liver cancer tissues with different AJCC stages,capsule integrity,and tumor metastasis(P<0.05).Multivariate logistic regression model analysis showed that AJCC stage,capsule integrity,and tumor metastasis were influence factors affecting the expression of HDGF and VEGF in liver cancer tissue(P<0.05).【Conclusions】HDGF and VEGF are highly expressed in liver cancer tissue,and are related to AJCC staging,capsule integrity,and tumor metastasis,which has certain reference value for evaluating liver cancer progression.
作者
王晓锋
王菁菁
WANG Xiao-feng;WANG Jing-jing(Xi'an Third Hospital Northwest University Hospital,Xi'an Shaanxi 710018)
出处
《医学临床研究》
CAS
2023年第6期920-923,共4页
Journal of Clinical Research
关键词
肝肿瘤/病理学
血管内皮生长因子A
肿瘤转移
肿瘤浸润
数据相关性
Liver Neoplasms/PA
Vascular Endothelial Growth Factor A
Neoplasm Metastasis
Neoplasm Invasiveness
Correlation of Data
