摘要
目的 探讨治疗前全身免疫炎症指数[血小板计数×中性粒细胞计数/淋巴细胞计数(SII)]与结直肠癌(CRC)患者临床病理及预后的相关性,阐明治疗前SII在CRC患者预后中的意义。方法 计算机检索PubMed、EMbase、Web of SCIence、Cochrane Library、中国知网及万方等数据库发表的关于SII对CRC患者预后影响的临床研究,检索时限为建库至2022年5月,根据纳入和排除标准筛选文献,采用STATA17.0统计软件对符合纳入标准的研究进行Meta分析,观察治疗前SII与CRC患者总生存期(OS)、无进展生存期(PFS)及临床病理特征的关系。结果 共检索74篇文献,最终纳入13篇文献共5 132例CRC患者。高SII组患者OS(HR=1.67,95%CI:1.29~2.17,P<0.001)和PFS(HR=1.74,95%CI:1.26~2.40,P=0.001)均明显低于低SII组;不同地理位置、样本量、治疗方式、TMN分期和纽卡斯尔-渥太华量表评分高SII组患者OS均明显低于低SII组,差异均有统计学意义(P<0.05)。治疗前高SII与低分化肿瘤、有远处转移、肿瘤位置在直肠及左半结肠处、东部合作肿瘤处理团体评分为1~2分、肿瘤最大径≥5 cm均有关,与性别、淋巴结转移、年龄均无关。结论 治疗前高SII意味着CRC的恶性程度更高,高SII与CRC患者预后不良有关。
Objective To investigate the correlation between systemic immune inflammation index[platelet count×neutrophil count/lymphocyte count(SII)]before treatment and clinicopathological and prognosis of colorectal cancer(CRC)patients,and to clarify the significance of SII before treatment in the prognosis of CRC patients.Methods Clinical studies on the effect of SII on the prognosis of CRC patients published in PubMed,EMbase,Web of SCIence,Cochrane Library,CNKI,and Wanfang databases were searched by computer from the establishment of the database to May 2022.Literature was screened according to the inclusion and exclusion criteria,and Meta-analysis was performed using STATA17.0 statistical software to observe the relationship between pretreatment SII and overall survival(OS),progression-free survival(PFS)and clinicopathological characteristics of CRC patients.Results A total of 74 articles were retrieved,and 13 articles involving 5132 CRC patients were included.OS(HR=1.67,95%CI:1.29-2.17,P<0.001)and PFS(HR=1.74,95%CI:1.26-2.40,P=0.001)in the high SII group were significantly lower than those in the low SII group.Different geographical location,sample size,treatment method,TMN stage and Newcastle-Ottawa scale score,the OS of patients in the high SII group was significantly lower than that in the low SII group,and the differences were statistically significant(P<0.05).Before treatment,high SII was associated with poorly differentiated tumors,distant metastasis,tumor location in the rectum and left hemicolon,Eastern Cooperative Oncology Group score of 1-2,and maximum tumor diameter≥5 cm,but not with gender,lymph node metastasis,or age.Conclusion High SII before treatment indicates a higher degree of CRC malignancy and high SII is associated with poor prognosis in CRC patients.
作者
侍科辰
张文斌
SHI Kechen;ZHANG Wenbin(Department of Gastrointestinal(tumor)Surgery,The First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830000,China)
出处
《检验医学与临床》
CAS
2023年第14期2017-2022,共6页
Laboratory Medicine and Clinic
基金
新疆维吾尔自治区自然科学基金项目(2022D01D77)。
关键词
全身免疫炎症指数
结直肠癌
临床病理
预后研究
META分析
systemic immune inflammation index
colorectal cancer
clinicopathology
prognosis research
Meta analysis
