摘要
白血病是一组高异质性克隆性血液肿瘤, 其发病机制尚未完全阐明。人源肿瘤异种移植(PDX)动物模型可以保留肿瘤的异质性、遗传学特征和肿瘤微环境, 为研究白血病的分子发病机制和开发新的治疗方法提供工具。笔者拟就白血病PDX动物模型构建的发展历程和PDX动物模型在各类白血病中应用的研究进展进行综述, 以期为研究者构建白血病PDX动物模型提供理论和方法依据, 使白血病PDX动物模型能够更好地为白血病患者的个体化用药提供指导, 为实现白血病精准治疗奠定基础。
Leukemia is a group of clonal hematopoietic malignancies with great heterogeneity,and its pathogenesis has not been fully clarified.Patient-derived tumor xenograft(PDX)animal model can well preserve the heterogeneity,genetic features and tumor microenvironment of tumor,providing a tool for studying the molecular pathogenesis of leukemia and developing new treatments.Therefore,this article summarizes research progress on development and construction of leukemia PDX animal model and application progress of PDX animal model in all kinds of leukemia.In order to provide theoretical and methodological basis for researchers to build leukemia PDX animal model,so that leukemia PDX animal model can provide better guidance for personalized medication leukemia patients,and lay foundation for the realization of leukemia precision medicine.
作者
谢焕
曾东风
Xie Huan;Zeng Dongfeng(Department of Hematology,Army Medical Center of PLA(Daping Hospital),Army Medical University,Chongqing 400042,China)
出处
《国际输血及血液学杂志》
CAS
2023年第2期180-184,F0003,共6页
International Journal of Blood Transfusion and Hematology
基金
陆军军医大学临床医学科研人才培养计划基金(2018XLC3068)。
