摘要
溶瘤病毒可以感染和破坏癌组织,是一种治疗癌症的新型生物疗法。溶瘤病毒在癌细胞中选择性复制,进而导致癌细胞裂解,释放肿瘤特异性抗原,诱导抗癌免疫反应,充当原位肿瘤疫苗。对病毒进入、复制、诱导和抑制免疫反应机制的深入了解促进了利用病毒治疗人类疾病技术的发展。过去十年溶瘤病毒领域临床试验的进展证实了其对癌症患者的治疗益处,利用溶瘤病毒作为载体治疗特定类型的癌症是肿瘤免疫治疗市场的新增长点。通过全面分析溶瘤病毒免疫治疗市场的细分领域及其市场动态,从关键技术进展、主要企业竞争格局和产品研发进展角度进行分析,并展望溶瘤病毒的发展前景,旨在为相关企业研发方向选择及地区产业决策提供参考。
Oncolytic viruses,capable of infecting and destroying malignant tissues,are becoming new biological therapies for treating cancers.Their ability in selectively replicating inside cancer cells and inducing lysis of certain cancer cells leads to the releasing of tumor-specific antigens for anti-cancer immune responses,acting as in situ cancer vaccines.The insights into the mechanisms of virus replication,entry,induction and inhibition of immune response have promoted the technology development of virus utilization in the treatment of certain human diseases.In the past decade,the progress of clinical trials in the field of oncolytic viruses has confirmed the therapeutic benefits in cancer therpy.Using oncolytic virus as a carrier of foreign genes to treat specific types of cancer is a feasible method,which could become new growth avenue of the cancer immunotherapy market.This article provides a comprehensive and multidimensional analysis of the niche areas and the dynamic changes from several aspects such as the oncolytic virus immunotherapy market,key technology progress,major enterprise competition pattern and product R&D progress,combined with a forecast of the prospects for the development of oncolytic viruses as a cancer therapy,for the purpose of providing reference in research and development direction selection and regional industrial decision-making for related companies.
作者
韩佳
范月蕾
毛开云
HAN Jia;FAN Yue-lei;MAO Kai-yun(Shanghai Information Center for Life Sciences,Shanghai Institute of Nutrition and Health,Chinese Academy of Sciences,Shanghai 200031,China)
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2023年第6期87-101,共15页
China Biotechnology
基金
上海市2023年度“科技创新行动计划”软科学研究(23692102702)
上海市2022年度“科技创新行动计划”软科学研究(22692102900)资助项目。
关键词
溶瘤病毒
竞争格局
研发格局
市场动态
肿瘤免疫治疗
癌症治疗
Oncolytic virus
Competitive pattern
R&D pattern
Market trends
Tumor immnuotherapy
Cancer treatment
