摘要
隐匿性乙型肝炎病毒感染(OBI)仍是输血后肝炎(Post transfusion hepatitis,PTH)的重要传染源之一。随着献血者血液筛查系统增设核酸检测技术(Nnucleic acid test,NAT),在一定程度上屏蔽了OBI引起的输血传播性疾病,残余风险度显著降低,但献血者中仍存在一些OBI感染者,增加了经血传播OBI的风险。地域差异、人群特征及检测试剂的灵敏度和特异性都对OBI的流行情况产生一定影响,进而影响无偿献血人群OBI的流行率。本文主要对OBI的相关概念、发病机制、国内外献血者中OBI的流行率、经典检测方法和传播情况以及如何管理进行概述。
Occult hepatitis B infection(OBI) is still one of the important infectious sources of post transfusion hepatitis(PTH).With the addition of the nucleic acid test(NAT) technology to the blood screening system for blood donors,the transfusion-borne diseases caused by OBI can be screened to a certain extent,and the residual risk degree is significantly reduced,but there are still some OBI infected blood donors,which increases the risk of OBI transmission through blood.Regional differences,population characteristics,and the sensitivity and specificity of detection reagents all have certain effects on the prevalence of OBI,and then affect the prevalence of OBI in non-remunerated blood donors.This article mainly summarizes the related concepts,pathogenesis,prevalence of OBI in blood donors at home and abroad,classical detection methods,transmission,and the ways to manage OBI.
作者
李凤园
潘彤
Li Fengyuan;Pan Tong(Tianjin Blood Center,Tianjin300110,China)
出处
《齐齐哈尔医学院学报》
2023年第11期1064-1070,共7页
Journal of Qiqihar Medical University
关键词
献血者
OBI
NAT
输血安全
Blood donors
OBI
NAT
Blood transfusion safety
