摘要
目的探讨逍遥丸对肝郁型轻度认知功能障碍(MCI)患者肝郁症状和认知功能的影响。方法采用逍遥丸对肝郁型MCI患者干预12 w,采用肝气郁结证症状程度计分表对患者的肝郁症状进行评价,采用蒙特利尔认知评估(MoCA)量表和三刺激听觉Oddball范式的事件相关电位成分失匹配负波(MMN)、P3a、P3b对患者的认知功能进行评价。结果与用药前相比,用药后肝气郁结证症状得分显著下降(P<0.05),MoCA量表的视空间与执行、注意、抽象、延迟回忆、定向得分均显著升高(P<0.05),MMN潜伏期显著缩短(P<0.05),P3a波幅显著增大(P<0.05),MMN波幅、P3a潜伏期及P3b的波幅和潜伏期未见明显变化(P>0.05)。结论逍遥丸可改善肝郁型MCI患者的肝气郁结症状和认知功能。
Objective To investigate the effect of Xiaoyao Pill on the symptoms of liver depression and cognitive function of mild cognitive impairment(MCI)patients with liver depression.Methods Xiaoyao pill was used to intervene in MCI patients with liver depression for 12 w,and the symptoms of liver depression were evaluated by using the score table of symptoms of liver qi stagnation syndrome.The montreal cognitive assessment(MoCA)scale and the mismatch negative(MMN),P3a and P3b of the three-stimulus auditory Oddball of the event-related potential were used to evaluate the cognitive function of the patients.Results Compared with before medication,the symptom score of liver qi stagnation syndrome was significantly decreased after medication(P<0.05).The scores of visual space and executive,attention,abstraction,delayed recall and orientation of MoCA scale were all significantly increased(P<0.05),the latency of MMN was significantly shortened(P<0.05),the amplitude of P3a was significantly increased(P<0.05),the amplitude of MMN,the latency of P3a,the amplitude and latency of P3b were not significantly changed(P>0.05).Conclusions Xiaoyao Pill could improve the symptoms of cognitive function and liver qi stagnation in MCI patients with liver depression.
作者
侯俊林
刘永
李宁
赵川
秦中朋
吕茹
闫国立
詹向红
HOU Jun-Lin;LIU Yong;LI Ning(Henan University of Traditional Chinese Medicine,Zhengzhou 450046,Henan,China)
出处
《中国老年学杂志》
CAS
北大核心
2023年第14期3404-3408,共5页
Chinese Journal of Gerontology
基金
国家自然科学基金资助项目(81473556,81873208)
河南中医药大学博士科研基金(BSJJ2020-02)。
关键词
逍遥丸
轻度认知功能障碍
事件相关电位
Xiaoyao pill
Mild cognitive impairment
Event-related potential
