摘要
目的:探究妊娠期亚临床甲状腺功能减退患者血清叶酸、维生素B_(12)及同型半胱氨酸(HCY)水平检测的临床应用价值.方法:选取2019年8月至2021年7月于本院行产前检查存在妊娠期亚临床甲状腺功能减退的50例孕妇纳入甲减组,另选取同期于本院例行产前检查甲状腺功能正常的40例孕妇纳入正常组.比较两组孕妇叶酸、维生素B_(12),HCY、TSH水平,分析血清HCY的影响因素.结果:相比于正常组,甲减组孕妇血清叶酸、维生素B_(12)水平均较低,HCY、促甲状腺激素(TSH)水平均较高,差异有统计学意义(P<0.05).Spearman相关性分析显示,血清HCY与叶酸及维生素B_(12)呈负相关关系(r=-0.234、-0.138,P=0.017、0.130),与TSH呈正相关关系(r=0.281,P=0.025).结论:通过分析血清叶酸、维生素B_(12)及HCY水平能够有效判断患者病情严重程度,在妊娠过程中需注意做好相关补充,避免对胎儿的生长发育造成影响.
Objective:To investigate the clinical value of serum folic acid,vitamin B_(12) and homocysteine(HCY)levels in patients with subclinical hypothyroidism during pregnancy.Methods:A total of 50 pregnant women with subclinical hypothyroidism during pregnancy who underwent antenatal examinations in our hospital from August 2019 to July 2021 were selected in the hypothyroidism group.Additionally,40 pregnant women with normal thyroid function who underwent routine antenatal examination in our hospital during the same period were selected in normal group.The levels of folic acid,vitamin B_(12),HCY,and TSH were compared between the two groups,and the influencing factors of serum HCY were analyzed.Results:Compared with the normal group,the levels of serum folic acid and vitamin B_(12) in hypothyroidism group were lower,and the levels of HCY and thyroid stimulating hormone(TSH)were higher,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that serum HCY was negatively correlated with folic acid and vitamin B_(12)(r=-0.234,-0.138,P=0.017,0.130),and positively correlated with TSH(r=0.281,P=0.025).Conclusion:The analysis of serum folic acid,vitamin B_(12) and HCY levels can effectively judge the severity of the patient's condition,and it is necessary to pay attention to the relevant supplements during pregnancy to avoid affecting the growth and development of the fetus.
作者
孙佳佳
王辉
SUN Jia-jia;WANG Hui(Department of Clinical Laboratory,Huaibin Maternal and Child Health Hospital,Xinyang 464400,China)
出处
《四川解剖学杂志》
2023年第1期84-86,共3页
Sichuan Journal of Anatomy
