摘要
目的:分析恶性肿瘤合并静脉血栓栓塞症(VTE)患者的危险因素。方法:选取2020年1月至2022年1月陆军第73集团军医院进行治疗的133例恶性肿瘤患者,对患者一般资料进行回顾性分析,比较恶性肿瘤组患者及恶性肿瘤合并VTE组患者一般资料,通过多因素logistic回归分析明确恶性肿瘤合并VTE的危险因素,比较两组患者1年死亡率。结果:两组患者肿瘤分期、冠心病、化疗、合并感染、激素治疗、中心静脉置管构成比及纤维蛋白原(FIB)、D-二聚体(D-D)、活化部分凝血活酶时间(APTT)、血管性血友病因子(vWF)水平比较,差异具有统计学意义(P<0.05);多因素logistic回归分析结果表明肿瘤分期Ⅲ~Ⅳ期、有冠心病、有化疗、有感染、有激素治疗及有中心静脉置管、血浆D-D水平高为恶性肿瘤合并VTE危险因素,差异具有统计学意义(P<0.05)。多因素logistic回归分析结果表明,肿瘤分期Ⅲ~Ⅳ期、有冠心病、有化疗、有感染、有激素治疗及有中心静脉置管、血浆D-D水平高为恶性肿瘤合并VTE危险因素(P<0.05);恶性肿瘤合并VTE组患者1年死亡率明显高于恶性肿瘤组患者,差异具有统计学意义(P<0.05)。结论:肿瘤分期Ⅲ~Ⅳ期、有冠心病、有化疗、有感染、有激素治疗及有中心静脉置管、D-D水平高为恶性肿瘤合并VTE危险因素,临床可根据相关危险因素早期采取防控措施,降低患者死亡率。
Objective To analyze the risk factors of malignant tumor patients with venous thromboembolism(VTE).Methods A retrospective analysis was conducted on 133 malignant tumor patients treated at the 73rd Army Group Military Hospital from January 2020 to January 2022.The general data of the patients were compared between the malignant tumor group and the malignant tumor combined with VTE group.The risk factors for malignant tumor combined with VTE were identified through multivariate logistic regression analysis,and the one-year mortality rate of the two groups of patients was compared.Results There were statistically significant differences between the two groups in tumor staging,coronary heart disease,chemotherapy,coinfection,hormone therapy,central venous catheterization ratio,and the levels of fibrinogen(FIB),D-dimer(D-D),activated partial thromboplastin time(APTT)and von willebrand factor(vWF)(P<0.05);The results of multivariate logistic regression analysis showed that tumor stageⅢ~Ⅳpresence of coronary heart disease,chemotherapy,infection,hormone therapy,central venous catheterization,and high plasma D-D levels were risk factors for malignant tumors with VTE,and the differences were statistically significant(P<0.05).The results of multivariate logistic regression analysis showed that tumor stageⅢ~Ⅳ,presence of coronary heart disease,chemotherapy,infection,hormone therapy,central venous catheterization,and high plasma D-D levels were risk factors for malignant tumors with VTE(P<0.05).The one-year mortality rate of patients with malignant tumors combined with VTE was significantly higher than that of patients with malignant tumors,and the difference was statistically significant(P<0.05).Conclusion Tumor stagingⅢ~Ⅳ,presence of coronary heart disease,chemotherapy,infection,hormone therapy,central venous catheterization,and high D-D levels are risk factors for malignant tumors with VTE.Early prevention and control measures can be taken according to relevant risk factors in clinical practice to reduce patien
作者
高会会
黄贵卿
雷敏
陈建清
GAO Hui-hui;HUANG Gui-qing;LEI Min;CHEN Jian-qing(The 73rd Army Group Military Hospital,Fujian Xiamen 361003)
出处
《深圳中西医结合杂志》
2023年第8期11-14,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词
恶性肿瘤
静脉血栓栓塞症
危险因素
防控措施
Malignant tumors
Venous thromboembolism
Risk factors
Prevention and control measures
