摘要
目的:研究膈肌刺激对呼吸机依赖重症颅脑损伤患者膈肌功能的影响。方法:采用随机数字表法将福建省立医院2020年1月-2022年12月收治的80例呼吸机依赖重症颅脑损伤患者分为两组。对照组(n=40)行常规对症治疗,研究组(n=40)在对照组基础上行膈肌刺激治疗。比较两组膈肌功能、呼吸状况、氧化应激反应、预后情况。结果:治疗后,研究组膈肌厚度、平静呼吸及深吸气后膈肌位移均高于对照组(P<0.05);治疗后研究组最大吸气压、呼气压及超氧化物歧化酶(SOD)水平均高于对照组,浅快呼吸指数(RSBI)及丙二醛(MDA)、谷胱甘肽(GSH)水平均低于对照组(P<0.05);研究组重新上机率低于对照组,重症监护病房(ICU)治疗时间短于对照组(P<0.05)。结论:膈肌刺激能够有效改善呼吸机依赖重症颅脑损伤患者膈肌功能与呼吸状况,减轻氧化应激反应,改善其预后。
Objective:To study the effect of diaphragm stimulation on diaphragm function in patients with ventilator dependency severe craniocerebral injury.Method:A total of 80 patients with ventilator dependency severe craniocerebral injury who were admitted to Fujian Provincial Hospital from January 2020 to December 2022 were divided into two groups according to random number table method.The control group(n=40)received routine symptomatic treatment,and the research group(n=40)received diaphragm stimulation on the basis of the control group.The diaphragm function,respiratory condition,oxidative stress response and prognostic situation were compared between the two groups.Result:After treatment,the diaphragm thickness and thickness ratio,diaphragm displacement after calm breathing and deep inhalation in the research group were higher than those in the control group(P<0.05).After treatment,the maximal inspiratory pressure and expiratory pressure and superoxide dismutase(SOD)levels in the research group were higher than those in the control group,while the rapid shallow breathing index(RSBI),the levels of malondialdehyde(MDA)and glutathione(GSH)were lower than those in the control group(P<0.05).The re-entry ventilator rate of the research group was lower than that of the control group,and the treatment time in the intensive care unit(ICU)was shorter than that of the control group(P<0.05).Conclusion:Diaphragm stimulation can effectively improve the diaphragm function and respiratory condition of patients with ventilator dependency severe craniocerebral injury,reduce oxidative stress response and improve their prognosis.
作者
陈开化
刘巧萍
于荣国
CHEN Kaihua;LIU Qiaoping;YU Rongguo(Medical University Provincial Clinical Medical College,Fuzhou 350001,China)
出处
《中国医学创新》
CAS
2023年第17期51-54,共4页
Medical Innovation of China
基金
福建省卫生计生青年科研课题(2017-2-1)。
关键词
重症颅脑损伤
呼吸机依赖
膈肌刺激
膈肌功能
Severe craniocerebral injury
Ventilator dependency
Diaphragm stimulation
Diaphragm function
