摘要
阿尔茨海默病是一种常见的神经退行性疾病。神经组织中淀粉样斑块的积累和Tau病理的传播在AD的发生发展中起关键作用。转化生长因子-β(TGF-β)超家族由几组高度保守的多功能信号蛋白组成,广泛参与细胞周期调控、分化和免疫等生理过程。TGF-β超家族具有神经保护功能,并在AD病理改变的多个方面起关键作用,包括Aβ沉积、Tau磷酸化、海马神经发生和突触可塑性障碍等。多种TGF-β超家族成员在AD模型中被证明可明显延缓其病程,改善认知功能障碍。本文对TGF-β超家族在AD病理学方面的相关研究进行了系统综述,表明TGF-β超家族的研究在AD治疗中具有巨大潜能。
Alzheimer's disease(AD)is a common neurodegenerative disease and is mainly attributed to the accumulation of amyloid plaques and the spread of Tau pathology.Transforming growth factor beta(TGF-β)superfamily consists of several groups of highly conserved multifunctional signaling proteins orchestrating many physiological processes including cell-cycle control,differentiation and immune functions.TGF-βsuperfamily has neuroprotective functions and plays a key role in multiple aspects of AD pathological changes,including Aβdeposition,Tau phosphorylation,hippocampal neurogenesis,and synaptic plasticity disorders.Multiple TGF-βsuperfamily members have been shown to significantly delay the course of disease and improve cognitive dysfunction in AD models.This study systematically reviewed the recent progress of TGF-βsuperfamily in the pathology of AD to reveal its tremendous potential on the research of AD.
作者
刘芬
李湘湘
邹伟
LIU Fen;LI Xiangxiang;ZOU Wei(Department of Neurology,Affiliated Nanhua Hospital,Hengyang Medical College,University of South China,Hengyang 421001,China)
出处
《生命的化学》
CAS
2023年第5期772-779,共8页
Chemistry of Life
基金
湖南省临床医疗技术创新引导项目(2020SK51908)
湖南省卫生健康委员会一般资助项目(202203074999)
湖南省卫生健康委员会一般指导项目(202203072781)。
