摘要
本体感受器是分布于骨骼肌和关节中感知躯体运动速度、速率变化及姿势维持等本体感觉信号的一类感受器,可将机械力信号转变为电信号并通过传入神经将信息传递至中枢神经系统。该文以脊椎动物最重要的本体感受器——肌梭为例,分析本体感受器中可能存在的离子通道,进一步探讨肌梭将机械力信号转变为电信号的分子机制,为本体感觉的电生理研究、相关药物研发及临床治疗提供一定的分子生物学基础。
Proprioceptors are distributed in skeletal muscles and joints to sense the body’s speed of motion,rate change,posture maintenance and other proprioceptive signals,which can transform mechanical force signals into electrical ones and transmit information to central nerves via afferent nerves.This paper takes proprioception-muscle spindles as an example to analyze the possible ion channels in proprioception-muscle spindles and the molecular mechanism by which muscle spindles transform mechanical force signals into electrical signals,providing molecular biological data for electrophysiological research on proprioception,development of related drugs and clinical treatment.
作者
洪剑
连苡涵
王海利
HONG Jian;LIAN Yi-han;WANG Hai-li(The Eighth Medical Center of PLA General Hospital,Beijing 100091,China;School of Nursing,Shandong University of TCM,Jinan 250355,China;Hongshankou Outpatient Department,Beijing North Medical District,PLA General Hospital,Beijing 100091,China)
出处
《军事医学》
CAS
CSCD
2023年第5期395-400,共6页
Military Medical Sciences
关键词
本体感觉
本体感受器
肌梭
机械力传递
离子通道
proprioception
proprioceptor
muscle spindle
mechanical force transmission
ion channel
