摘要
目的探讨不同甘油三酯相关指标,即甘油三酯高密度脂蛋白胆固醇比值(triglyceride to high density lipoprotein cholesterol ratio,TG/HDL-C)、甘油三酯葡萄糖乘积指数(triglyceride glucose index,TyG指数)及相关参数与非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的相关性及在NAFLD疾病预测中的应用价值。方法选取2022年1—4月在新疆医科大学第一附属医院参与健康检查的608例体检者为研究对象;根据B型超声影像学参数结果,分为NAFLD组(328例)和非NAFLD组(280例),比较两组间各临床相关指标差异;采用logistic回归分析五种甘油三酯相关指标与NAFLD之间的相关性,并运用受试者工作特征曲线(receiver operating characteristic curve,ROC)进一步分析其在NAFLD疾病筛查中的预测价值。结果logistic回归分析结果显示,在五种甘油三酯相关指标中,无论调整混杂因素前或后,均以TyG指数-腰高比(triglyceride glucose index-waist height ratio,TyG-WHtR)的比值比最为显著,分别为13.485(95%CI:8.919~20.389)和12.559(95%CI:7.729~20.405)。ROC曲线结果分析显示,五种甘油三酯相关指标预测NAFLD的ROC曲线下面积(area under the curve,AUC)均大于0.7(P<0.05);其中,TyG指数-体质指数(triglyceride glucose index-body mass index,TyG-BMI)在18~40岁男性受试者中预测NAFLD的AUC最大,为0.871(95%CI:0.797~0.926);TyG指数-腰围(triglyceride glucose index-waist circumference,TyG-WC)预测总体男性、女性、体质指数(body mass index,BMI)<24人群以及40岁以上女性受试者的AUC最大,分别为0.850(95%CI:0.805~0.888)、0.908(95%CI:0.869~0.938)、0.840(95%CI:0.783~0.888)和0.913(95%CI:0.864~0.949);TyG-WHtR预测BMI≥24人群、18~40岁女性受试者以及40岁以上男性受试者的AUC最大,分别为0.803(95%CI:0.761~0.841)、0.904(95%CI:0.835~0.952)和0.851(95%CI:0.791~0.899)。结论TG/HDL-C、TyG指数及相关参数与NAFLD密切相关,其中与TyG指数相关的参数对NAFLD具有更高的预测价值�
Objective To explore the correlation of different triglyceride related indicators,namely triglyceride to high density lipoprotein cholesterol ratio(TG/HDL-C) and triglyceride glucose index(TyG) and their related parameters,with non-alcoholic fatty liver disease(NAFLD) and their application values in the prediction of NAFLD.Methods Six hundred and eight physical examinees in the First Affiliated Hospital of Xinjiang Medical University from January to April 2022 were selected as the subjects,and then they were divided into the NAFLD group(n=328) and the non-NAFLD group(n=280) according to the results of B-type ultrasound imaging parameters.The differences in the clinical related indexes were compared between the two groups.Logistic regression was used to analyze the correlation of five triglyceride related indicators with NAFLD,and receiver operating characteristic curve(ROC curve) was used to further analyze their predictive values in the screening of NAFLD. Results The results of logistic regression analysis showed that both before and after adjusting for potential confounding factors,the odds ratio of triglyceride glucose index-waist height ratio(TyG-WHtR) was the most significant among the five triglyceride related indicators,which was 13.485(95%CI:8.919-20.389) and 12.559(95%CI:7.729-20.405) respectively.ROC curve analysis displayed that the areas under receiver operating characteristic curves(AUCs) of the five triglyceride related indexes for predicting NAFLD were all greater than 0.7(allP<0.05).Among them,the AUC of triglyceride glucose index-body mass index(TyG-BMI) in predicting NAFLD among male subjects aged 18-40 years was the largest,which was 0.871(95%CI:0.797-0.926).The AUCs of triglyceride glucose index-waist circumference(TyG-WC) in predicting NAFLD among overall males,females,population with body mass index(BMI) 24 and females over 40 years old were the largest,which were 0.850(95%CI:0.805-0.888),0.908(95%CI:0.869-0.938),0.840(95%CI:0.783-0.888) and 0.913(95%CI:0.864-0.949) respectively.The AUCs of
作者
王仁媛
咸亚静
林栋羚
何丽
林素兰
WANG Ren-yuan;XIAN Ya-jing;LIN Dong-ling;HE Li;LIN Su-lan(School of Nursing,Xinjiang Medical University,Urumqi,Xinjiang 830011,China;The First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830054,China;Personnel Department of Xinjiang Medical University,Urumqi,Xinjiang 830011,China)
出处
《实用预防医学》
CAS
2023年第6期693-699,共7页
Practical Preventive Medicine
基金
新疆维吾尔自治区自然科学基金资助项目(2021D01C270)。
