摘要
利用微流控芯片技术制备的皮升级微量液滴,作为独立的微反应器,由于其比表面大,高通量等优势,在生物、医学、化学、物理等领域得到了广泛应用。本工作利用软光刻技术制备流聚焦型微流控芯片,研究了微流控芯片中连续相和分散相的流速对微量液滴尺寸的影响。结果显示,增加连续相流速时,微量液滴的尺寸减小;而加快分散相流速时,微量液滴的尺寸增大。当微流控芯片的通道尺寸固定后,由于分散相和连续相的界面张力不变,通过改变连续相和分散相的流速,微量液滴的尺寸范围有限,本工作中微量液滴的尺寸为几百微米至25μm。本工作探究了微流控芯片中如何制备尺寸小于25μm的微量液滴的方法。通过添加活性剂,改变连续相和分散相的界面张力,可实现制备尺寸为10μm的微量液滴。本工作所利用的微量液滴制备方法,制备的10μm大小液滴具备更高的比表面积,反应活性将会更大、在药物释放,颜色显示等领域将有广阔应用前景。
As an independent microreactor,the microfluidic microdroplet prepared by microfluidic chip technology has been widely used in the fields of biology,medicine,chemistry and physics due to its advantages of being larger than the surface and high throughput.In this paper,a flow-focused microfluidic chip was prepared by soft lithography.The influence of flow velocity of continuous phase and dispersed phase on the size of microdroplet was studied.The results show that the microdroplet size decreases when the flow rate of continuous phase is increased.When the flow rate of dispersed phase is increased,the size of microdroplet increases.When the channel size of the microfluidic chip is fixed,due to the constant interfacial tension between the dispersed phase and the continuous phase,the size range of the microdroplet is limited by changing the flow velocity of the continuous phase and the dispersed phase.In this paper,the size of the microdroplet ranges from several hundred microns to 25 microns.In this paper,the method of preparing microdroplet with size less than 25 microns in microfluidic chip is explored.By adding active agent and changing the interfacial tension between the continuous phase and the dispersed phase,microdroplets with the size of 10 microns can be prepared.The microdroplet preparation method used in this paper can prepare 10-micron droplets with larger specific surface area and greater reactivity,which will have a wide application prospect in drug release,color display and other fields.
作者
夏威
何荣祥
XIA Wei;HE Rongxiang(Department of Electronic Engineering,Huizhou TechnicianInstitute,Huizhou 516003,Guangdong,China;School of Optoelectronic Materials and Technology,JianghanUniversity,Wuhan 430056,China)
出处
《材料导报》
CSCD
北大核心
2023年第S01期505-507,共3页
Materials Reports
基金
武汉市应用基础前沿计划(2019020701011440)。
