摘要
目的比较戊酸雌二醇不同剂量与给药频次用于中度宫腔粘连腹腔镜术后治疗的效果。方法选取2019年5月—2021年5月福建医科大学附属泉州第一医院收治的中度宫腔粘连患者80例,采用随机数字表方法分为低频次组和高频次组,各40例。2组患者均行腹腔镜联合宫腔镜下宫腔粘连分离术,术后低频次组予戊酸雌二醇3 mg口服,每天2次;高频次组予戊酸雌二醇片2 mg口服,每天3次,2组均以21 d为1个周期,共治疗4个周期。比较2组治疗效果,术前1周、用药1周后及用药3周后雌激素水平与子宫内膜厚度变化,治疗结束后患者月经量恢复正常患者比例、经期时间,随访6个月后患者妊娠以及复发情况。结果低频次组与高频次组治疗总有效率比较差异无统计学意义(87.50%vs.85.00%,χ^(2)=0.105,P=0.745);用药1周、3周后,2组雌激素水平与子宫内膜厚度均较术前1周明显增加,差异均有统计学意义(P均<0.01),2组同期比较差异无统计学意义(P>0.05);低频次组与高频次组月经量恢复正常率比较差异无统计学意义(82.50%vs.75.00%,χ^(2)=0.672,P=0.412);低频次组与高频次组经期时间比较差异亦无统计学意义(t=0.653,P=0.516);低频次组与高频次组妊娠率(45.00%vs.40.00%)与复发率(7.50%vs.12.50%)比较差异均无统计学意义(P均>0.05)。结论戊酸雌二醇不同剂量与给药频次用于中度宫腔粘连腹腔镜术后治疗的效果相近,均能够有效促进子宫内膜的增殖生长及月经恢复,并可改善妊娠结局,预防宫腔粘连复发,临床可根据患者实际病情选择合适的方案。
Objective To compare the efficacy of different doses and frequency of estradiol valerate in the treatment of moderate intrauterine adhesions after laparoscopic surgery.Methods A total of 80 patients with moderate intrauterine adhesions admitted to Quanzhou First Hospital Affiliated to Fujian Medical University from May 2019 to May 2021 were selected.All patients were divided into a low-frequency group and a high-frequency group using a random number table method,with 40 patients in each group.Both groups of patients underwent laparoscopic and hysteroscopic separation of uterine adhesions.After surgery,the low-frequency group was orally administered 3 mg of estradiol valerate twice a day.The high-frequency group was given 2 mg of estradiol valerate orally three times a day.Both groups were treated for a total of 4 cycles,with 21 days as one cycle.Compare the treatment effects of the two groups.Compare the changes in estrogen levels and endometrial thickness 1 week before surgery,1 week after medication,and 3 weeks after medication.Compare the proportion and duration of patients whose menstrual flow returns to normal after treatment.After a follow-up of 6 months,compare the pregnancy and recurrence rates between the two groups of patients.Results There was no statistically significant difference in the total effective rate between the low-frequency group and the high-frequency group(87.50%vs.85.00%,χ^(2)=0.105,P=0.745).After 1 week and 3 weeks of medication,the levels of estrogen and endometrial thickness in both groups significantly increased compared to the first week before surgery,with statistical significance(P<0.01).There was no significant difference between the two groups during the same period(P>0.05).There was no statistically significant difference in the recovery rate of menstrual flow between the low-frequency group and the high-frequency group(82.50%vs.75.00%,χ^(2)=0.672,P=0.412).There was no statistically significant difference in menstrual time between the low-frequency group and the high-frequenc
作者
刘佳
伍丹丹
余黎吉
邱小梅
LIU Jia;WU Dandan;YU Liji;QIU Xiaomei(Obstetrics and Gynecology Department,Quanzhou First Hospital Affiliated to Fujian Medical University,Fujian Province,Quanzhou 362000,China)
出处
《临床合理用药杂志》
2023年第20期20-23,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
宫腔粘连
雌激素
戊酸雌二醇
用药频次
子宫内膜
Uterine adhesions
Estrogen
Estradiol valerate
Medication frequency
Endometrium
