摘要
目的:探讨银杏二萜内酯联合依达拉奉对急性缺血性脑卒中(AIS)患者疗效及氧化应激和细胞因子影响。方法:选自本院于2020年6月—2022年1月收治的AIS患者100例,运用随机表法将入组患者分为两组,各50例。对照组给予依达拉奉注射液30 mg+100 ml氯化钠注射液静脉滴注,2次/d;观察组在对照组基础上给予银杏二萜内酯葡胺注射液5 ml+250 ml氯化钠注射液静脉滴注,1次/d。两组连续治疗14 d。比较两组治疗疗效、治疗前后日常生活活动能力量表(ADL)和神经功能缺损程度(NIHSS)评分、氧化应激、细胞因子变化及不良反应。结果:观察组AIS患者总有效率高于对照组(P<0.05)。两组治疗前AIS患者ADL评分和NIHSS评分比较差异无统计学意义(P>0.05);两组治疗后AIS患者ADL评分高于治疗前,而AIS患者NIHSS评分低于治疗前(P<0.05);观察组治疗后AIS患者ADL评分高于对照组,而AIS患者NIHSS评分低于对照组(P<0.05)。两组治疗前AIS患者血清还原型谷胱甘肽(GSH)、超氧化物歧化酶(SOD)和丙二醛(MDA)水平比较差异无统计学意义(P>0.05);两组治疗后AIS患者血清GSH和SOD水平高于治疗前,而AIS患者MDA水平低于治疗前(P<0.05);观察组治疗后AIS患者血清GSH和SOD水平高于对照组,而AIS患者MDA水平低于对照组(P<0.05)。两组治疗前AIS患者血清白介素-1β(IL-1β)、白介素-17(IL-17)和肿瘤坏死因子-α(TNF-α)水平比较差异无统计学意义(P>0.05);两组治疗后AIS患者血清IL-1β、IL-17和TNF-α水平低于治疗前(P<0.05);观察组治疗后AIS患者血清IL-1β、IL-17和TNF-α水平低于对照组(P<0.05)。两组不良反应无明显差异(P>0.05)。结论:银杏二萜内酯联合依达拉奉对AIS患者疗效显著,可调节患者氧化应激紊乱,减轻细胞炎性反应。
Objective:To investigate the effect of ginkgo diterpene lactone combined with edaravone on oxidative stress and cytokines in patients with acute ischemic stroke(AIS).Methods:A total of 100 patients with AIS admitted to our hospital from June 2020 to January 2022 were selected and divided into two groups,with 50 cases in each groupby randomized table method.The control group was intravenously injected with edaravone injection(30 mg+100 ml sodium chloride injection),twice a day.On the basis of the control group,the observation group was intravenously injected with ginkgo diterpene lactone glucosamine injection(5 ml+250 ml of sodium chloride injection),once a day.The two groups were treated continuously for 14 days.The therapeutic effects,ADL and NIHSS scores before and after treatment,oxidative stress and cytokine changes,and adverse reactions were compared between the two groups.Results:The total effective rate of AIS patients in the observation group was higher than in the control group(P<0.05).There was no significant difference in ADL score and NIHSS score between the two groups before treatment(P>0.05).The ADL score of AIS patients after treatment was higher than that before treatment,while the NIHSS score of AIS patients was lower than before treatment(P<0.05).After treatment,the ADL score of AIS patients in the observation group was higher than in the control group,while the NIHSS score of AIS patients was lower than that in the control group(P<0.05).There was no significant difference in serum GSH,SOD,and MDA levels between the two groups before treatment(P>0.05).After treatment,the serum GSH and SOD levels of AIS patients were higher than before treatment,while MDA levels of AIS patients were lower than before treatment(P<0.05).After treatment,the serum GSH and SOD levels in AIS patients in the observation group were higher than those in the control group,while the MDA levels in AIS patients were lower than those in the control group(P<0.05).There were no significant differences in serum levels of IL-1β,I
作者
贺文奇
肖辉
黄萍
He Wenqi;Xiao Hui;Huang Ping(Ji'an Central People's Hospital,Jiangxi 343000)
出处
《天津药学》
2023年第3期29-32,共4页
Tianjin Pharmacy
