摘要
目的分析拟输血、术前和产前备血患者不规则抗体检出及分布情况,探究不规则抗体筛查的重要意义,保证临床输血安全。方法选取2020年1—12月厦门大学附属第一医院收治的18479例拟输血和术前备血患者作为研究对象,采用IH-1000全自动血型分析仪检测系统进行不规则抗体筛查,对筛查阳性样本进行抗体鉴定,并分析年龄、性别、输血史、妊娠史、就诊科室对不规则抗体检出率的影响。结果抗体筛查共有166例抗体筛查阳性,阳性率为0.90%。其中Rh血型系统抗体61例,占比36.75%;MNS血型系统抗体39例,占比23.49%;P血型系统2例,占比1.20%;Lewis血型系统抗体7例,占比4.22%;Kidd血型系统抗体2例,占比1.20%;自身抗体33例,占比19.88%;混合抗体7例,占比4.22%;未确定特异性抗体15例,占比9.03%。在Rh血型系统中检出抗-E 34例,占比55.73%;在MNS血型系统中检出抗-M 34例,占比87.18%;在自身抗体中检出自身类-e抗体1例,占比3.03%。进行不规则抗体检出率影响因素分析,不同年龄段间比较差异无统计学意义,女性不规则抗体检出率高于男性,差异有统计学意义(P<0.05);有输血史和妊娠史患者的不规则抗体检出率高于无输血史和妊娠史患者,差异有统计学意义(P<0.05);内科不规则抗体检出率最高,为1.61%,妇产科不规则抗体检出率最低,为0.60%,各科室比较差异有统计学意义(P<0.05)。结论加强拟输血或输血后患者不规则抗体的筛查,可保证临床用血安全,加强孕期不规则抗体筛查,可保证孕妇和胎儿生命安全。
Objective To analyze the detection and distribution of irregular antibodies in patients with blood transfusion,preoperative and prenatal blood preparation,explore the significance of irregular antibody screening,and ensure the safety of clinical blood transfusion.Methods A total of 18479 patients with blood transfusion and preoperative blood reserve admitted to the First Affiliated Hospital of Xiamen University from January to December 2020 were selected as the research subjects,and the IH-1000 automatic blood group analyzer detection system was used to screen irregular antibodies,and the antibody identification of the screened positive samples was performed,and the effects of age,sex,blood transfusion history,pregnancy history and department on the detection rate of irregular antibodies were analyzed.Results A total of 166 cases of antibody screening were positive,with a positive rate of 0.90%.There were 61 cases of Rh blood group system antibodies,accounting for 36.75%;39 cases of MNS blood group system antibodies,accounting for 23.49%;2 cases of P blood group system,accounting for 1.20%;7 cases of Lewis blood group system antibodies,accounting for 4.22%;2 cases of Kidd blood group system antibodies,accounting for 1.20%;33 cases of autoantibodies,accounting for 19.88%;7 cases of mixed antibodies,accounting for 4.22%;15 cases of unidentified specific antibodies,accounting for 9.03%.34 cases of anti-E were detected in the Rh blood group system,accounting for 55.73%,and 34 cases of anti-M were detected in the MNS blood group system,accounting for 87.18%;among autoantibodies,1 case of auto-e antibody was detected,accounting for 3.03%.The influencing factors of irregular antibody detection rate were analyzed,and there was no significant difference between different age groups,and the detection rate of irregular antibodies in women was higher than that in men,and the difference was statistically significant(P<0.05).The detection rate of irregular antibodies in patients with blood transfusion history and pregnancy his
作者
缪小龙
郑艳玲
洪强
MIAO Xiaolong;ZHENG Yanling;HONG Qiang(Department of Blood Transfusion,The First Affiliated Hospital of Xiamen University,Xiamen,Fujian,361003,China)
出处
《当代医学》
2022年第28期83-87,共5页
Contemporary Medicine
关键词
不规则抗体
RH血型
分布特点
输血安全
Irregular antibodies
Rh blood group
Distribution characteristics
Blood transfusion safety
