摘要
目的探讨舌下免疫治疗尘螨过敏哮喘儿童的临床疗效。方法选取2016年5月至2021年1月本院收治的200例尘螨过敏哮喘患儿作为研究对象,按照随机数字表法分为观察组和对照组,每100例。对照组采用吸入性糖皮质激素治疗,观察组在对照组基础上采用舌下含服粉尘螨滴剂治疗,比较两组临床疗效、哮喘昼夜症状评分、视觉模拟评分法(VAS)评分和治疗前后呼出气一氧化氮(FeNO)、嗜酸性粒细胞(EOS)、免疫指标[干扰素-γ(INF-γ)、血清白细胞介素-4(IL-4)、血清尘螨免疫球蛋白G(SIgG4)]水平及不良反应发生情况。结果观察组治疗总有效率(92.00%)明显高于对照组(76.00%),差异有统计学意义(P<0.05)。治疗后,两组日间、夜间症状评分及VAS评分均低于治疗前,且观察组明显低于对照组,差异有统计学意义(P<0.05)。治疗后,两组FeNO及EOS水平均低于治疗前,且观察组明显低于对照组,差异有统计学意义(P<0.05)。治疗后,两组SIgG4、INF-γ水平均明显高于治疗前,IL-4水平明显低于治疗前,且观察组SIgG4、INF-γ水平均明显高于对照组,IL-4水平明显低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为2.00%,低于对照组的10.00%,差异有统计学意义(P<0.05)。结论舌下免疫治疗尘螨过敏哮喘儿童疗效理想,可减轻哮喘症状及气道炎症反应,促进免疫功能恢复,安全性较高,值得临床推广应用。
Objective To investigate the clinical efficacy of sublingual immunotherapy in children with dust mite allergic asthma.Methods 200 children with dust mite allergy and asthma admitted from May 2016 to January 2021 were selected as the research subjects,and they were divided into the observation group and the control group according to random number table method,with 100 cases in each group.The control group was treated with inhaled glucocorticoids,and the observation group was treated with subetongue dust mite drops on the basis of the control group,the clinical efficacy,asthma circadian symptom score,visual analogue score(VAS)score and levels of nitric oxide(FeNO),eosinophil(EOS),immune index[interferon-γ[INF-γ],serum interleukin-4[IL-4],serum dust mite immunoglobulin G(SIgG4)]before and after treatment and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group(92.00%)was significantly higher than that of the control group(76.00%),and the difference was statistically significant(P<0.05).After the treatment,the daytime and nighttime symptom scores and VAS scores of the two groups were lower than those before the treatment,and the observation group was significantly lower than the control group,and the differences were statistically significant(P<0.05).After the treatment,the FeNO and EOS levels in the two groups were lower than those before the treatment,and the observation group was significantly lower than the control group,and the differences were statistically significant(P<0.05).After treatment,SIgG4 and INF-γlevels in the two groups were significantly higher than before treatment,and IL-4 levels were significantly lower than before treatment,and SIgG4 and INF-γlevels in observation group were significantly higher than control group,and IL-4 levels were significantly lower than control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 2.00%,which was lower th
作者
黄怡玲
李丰
唐盈
郑可鲁
HUANG Yiling;LI Feng;TANG Ying;ZHENG Kelu(Department of Rheumatology and Immunology,GuangzhouWomen and Children Medical Center,Guangzhou,Guangdong,510623,China;Department of Neurology,GuangzhouWomen and Children Medical Center,Guangzhou,Guangdong,510623,China)
出处
《当代医学》
2022年第34期74-77,共4页
Contemporary Medicine
基金
广州市市卫健委课题(20171A0102272)。
关键词
舌下免疫治疗
尘螨过敏哮喘
儿童
哮喘症状
免疫指标
Sublingual immunotherapy
Dust mite allergy
Asthma
Children
Asthma symptoms
Immune indicators
