摘要
目的分析活血止痛汤对胫骨平台骨折患者术后下肢静脉血栓(DVT)形成、凝血指标及关节功能的影响。方法选取2019年6月至2022年6月于山东省临沂市兰陵县人民医院进行胫骨平台骨折治疗的105例患者资料进行分析,根据治疗方法将其分为对照组(52例,常规治疗)和观察组(53例,常规治疗+活血止痛汤),观察两组治疗前、治疗4周后的凝血功能[凝血酶原时间(PT),活化部分凝血酶原时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)]水平、比较两组治疗前、治疗4周后视觉模拟疼痛量表(VAS)评分、美国特种外科医院(HSS)评分、下肢深静脉血栓形成率及不良反应。结果治疗后,观察组PT、APTT水平高于对照组,FIB、D-D水平低于对照组,差异有统计学意义(P<0.05);观察组VAS评分和中医症候积分低于对照组,差异有统计学意义(P<0.05);观察组HSS评分、屈曲角度和活动范围均高于对照组,差异有统计学意义(P<0.05);观察组下肢静脉血栓发生率为1.89%,低于对照组的13.46%,差异有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论活血止痛汤可改善胫骨平台骨折术后患者膝关节功能和关节活性度,缓解疼痛和中医症候积分症状,还能有效预防下肢深静脉血栓,具有较高的安全性。
Objective To analyze the effects of Huoxue Zhitong Decoction on the formation of lower extremity venous thrombosis(DVT),coagulation indexes and joint function in patients with tibial plateau fracture after operation.Methods Data of 105 patients treated for tibial plateau fracture in Lanling County People's Hospital of Linyi City,Shandong Province from June 2019 to June 2022 were selected and analyzed.Ac⁃cording to treatment methods,they were divided into the control group(52 cases,conventional treatment)and the observation group(53 cases,conventional treatment+Huoxue Zhitong decoction).The blood coagulation function[prothrombin time(PT),activated partial prothrombin time(APTT),fibrinogen(FIB),D⁃dimer(D⁃D)]levels,the visual analogue scale(VAS)score,Hospital for Special Surgery(HSS)score,lower ex⁃tremity deep vein thrombosis rate and adverse reactions were compared between the two groups before and after 4 weeks of treatment.Results After treatment,the levels of PT and APTT in the observation group were higher than those in the control group,while the levels of FIB and D⁃D in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).The VAS score and TCM symptom score in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).The HSS score,flexion angle and range of motion in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).The incidence of lower limb venous thrombosis in the observation group was 1.89%,lower than 13.46%in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Huoxue Zhitong Decoction can improve knee joint function and joint activity in patients with tibial plateau fracture,relieve pain and TCM symptoms,and can effectively prevent deep vein thrombosis of lower extre
作者
时坤
孟凡军
冯哲
SHI Kun;MENG Fanjun;FENG Zhe(Department of the Orthopaedic Trauma,People's Hospital of Lanling County,Linyi,Shandong,China,277799;Department of the Orthopaedic,the First Affiliated Hospital of Shandong Medical Colleg,Linyi,Shandong,China,276002)
出处
《分子诊断与治疗杂志》
2023年第6期990-993,共4页
Journal of Molecular Diagnostics and Therapy
基金
山东省医药卫生科技发展计划项目(2019WS0553)。
