摘要
目的:探讨小剂量甲泼尼龙辅助阿奇霉素治疗小儿肺炎的临床效果。方法:选取2021年1月—2022年8月泰安市妇幼保健院收治的94例肺炎患儿作为研究对象,根据随机数字表法分为对照组与观察组,各47例。对照组采用阿奇霉素序贯治疗,观察组在对照组基础上采用小剂量甲泼尼龙治疗。比较两组治疗效果。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.003)。观察组高热、咳嗽、肺啰音消退时间均短于对照组,差异有统计学意义(P<0.001)。治疗后,观察组C反应蛋白、肿瘤坏死因子-α、白细胞介素-6、CD8+水平均低于对照组,CD4+水平高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:肺炎患儿应用小剂量甲泼尼龙辅助阿奇霉素治疗,提高了治疗效果,炎症程度有效减轻,提升患儿免疫力,促进快速康复,并具有较好的治疗安全性。
Objective:To explore the the clinical effect of low-dose methylprednisolone assisted azithromycin in the treatment of infantile pneumonia.Methods:A total of 94 children with pneumonia who were treated in Taian Maternity and Child Health Hospital from January 2021 to August 2022 were selected as the study subjects.According to the random number table method,they were divided into control group and observation group,with 47 cases in each group.The control group was given azithromycin sequential therapy,and the observation group was treated with low-dose methylprednisolone on the basis of control group.The treatment effects in the two groups were compared.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.003).The time of high fever,cough and pulmonary rale disappearance in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.001).After treatment,the levels of C-reactive protein,tumor necrosis factor-α,interleukin-6 and CD8+in the observation group were lower than those in the control group,and the CD4+levels in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:For children with pneumonia,low-dose methylprednisolone assisted azithromycin treatment has improved the therapeutic effect,effectively reduced the degree of inflammation,improved the immunity of children,promoted rapid recovery,and has good therapeutic safety.
作者
王姿欢
Wang Zihuan(Pharmacy Department,Taian Maternity and Child Health Hospital,Taian 271000,Shandong Province,China)
出处
《中国社区医师》
2023年第17期13-15,共3页
Chinese Community Doctors
关键词
甲泼尼龙
阿奇霉素
小儿肺炎
安全性
Methylprednisolone
Azithromycin
Infantile pneumonia
Safety
