摘要
目的探讨玉米须水提物对初诊轻症2型糖尿病(T2DM)老年患者糖脂代谢及肝肾功能的影响。方法2020年6月至10月在齐齐哈尔医学院附属第二医院招募初诊轻症T2DM老年患者72例,采用随机数字表法将其分为干预组和对照组,各36例。干预组服用玉米须水提物(4.8 g/d),对照组给予等量的吐司粉作为安慰剂。比较两组糖脂代谢和肝肾功能指标。结果治疗后,干预组空腹胰岛素、胰岛素抵抗指数、丙氨酸转氨酶、天冬氨酸转氨酶低于治疗前,胰岛素敏感指数、总胆红素高于治疗前,对照组空腹血糖高于治疗前,干预组空腹血糖、空腹胰岛素、胰岛素抵抗指数、总胆固醇、天冬氨酸转氨酶、总胆红素均低于对照组,胰岛素敏感指数高于对照组,差异有统计学意义(P<0.05)。结论玉米须水提物可改善初诊轻症T2DM老年患者的空腹血糖及胰岛素抵抗,调节血清胆固醇水平,提高内源性抗氧化能力,对肝肾功能无不良影响。
Objective To investigate the effect of corn silk aqueous extract on glucose and lipid metabolism,liver and kidney function in newly diagnosed mild type2 diabetes mellitus(T2DM)elderly patients.Methods A total of 72 newly diagnosed mild T2DM elderly patients were recruited from the Second Affiliated Hospital of Qiqihar Medical College from June to October 2020,and they were divided into intervention group and control group by random number table method,with 36 cases in each group.The patients in the intervention group took 4.8 g corn silk aqueous extract every day,and the control group was given the same amount of toast powder as placebo.The indexes of glucose and lipid metabolism,liver,and kidney function were compared between the two groups.Results After treatment,fasting insulin,insulin resistance index,alanine aminotransferase,and aspartate aminotransferase in the intervention group were lower than before treatment,insulin sensitivity index,and total bilirubin were higher than before treatment,fasting blood glucose in the control group was higher than before treatment,and fasting blood glucose,fasting insulin,insulin resistance index,total cholesterol,aspartate aminotransferase and total bilirubin in the intervention group were lower than before treatment,insulin sensitivity index was higher than control group,the differences were statistically significant(P<0.05).Conclusion The intervention of corn silk aqueous extract can improve fasting blood glucose and insulin resistance,regulate blood lipid,have no adverse effect on liver and kidney function in elderly patients with newly diagnosed mild T2DM.
作者
程宇
杨文钦
钞虹
齐磊
周忠光
刘吉成
关宏
CHENG Yu;YANG Wenqin;CHAO Hong;QI Lei;ZHOU Zhongguang;LIU Jicheng;GUAN Hong(School of Public Health,Qiqihar Medical University,Heilongjiang Province,Qiqihar 161006,China;Postdoctoral Workstation,Research Institute of Medical and Pharmacy,Heilongjiang Province,Harbin 150000,China)
出处
《中国医药导报》
CAS
2023年第18期78-82,共5页
China Medical Herald
基金
黑龙江省中医药科研项目(ZHY2020-180)
黑龙江省省属高等学校基本科研业务费科研项目(2019-KYYWF-1212)。
关键词
玉米须水提物
2型糖尿病
糖脂代谢
肝肾功能
Corn silk aqueous extract
Type 2 diabetes me-llitus
Glucose and lipid metabolism
Liver and kidney function
