摘要
目的探究直肠癌保肛术后低位前切除综合征发生情况及危险因素。方法选择148例行保肛手术治疗的直肠癌患者,所有患者均行保肛手术。依据患者术后是否发生LARS,将患者分为无LARS组(n=95)及LARS组(n=53)。分析影响直肠癌保肛术后LARS发生的相关危险因素。结果LARS组低位肿瘤、术前放疗、吻合口位置距离肛缘≤5 cm发生率均高于无LARS组,差异有统计学意义(P<0.05);多因素分析显示,肿瘤位置(β=1.823,OR=6.187,95%CI:2.944~13.005)、术前放疗(β=2.611,OR=13.610,95%CI:2.914~63.572)及吻合口位置(β=3.269,OR=26.286,95%CI:10.260~67.342)是影响直肠癌保肛术后LARS发生的独立危险因素(P<0.05)。结论LARS为直肠癌保肛术后常见并发症,肿瘤位置、术前放疗及吻合口位置均是保肛术后LARS发生的重要影响因素,在临床干预中需予以重视。
Objective To investigate the occurrence and risk factors of low anterior resection syndrome after anal preservation in rectal cancer.Methods 148 patients treated with anal preservation surgery all underwent anal preservation surgery.Patients were divided into LARS and LARS groups(n=95)according on whether LARS occurred(n=53).Relevant risk factors affecting the occurrence of LARS after anal preservation in rectal cancer were analyzed.Results The incidence of low tumor,preoperative radiotherapy,and 5cm from anal margin were higher in LARS group than those without LARS,The difference was statistical significant(P<0.05);Multivariate analysis revealed that,tumour location(β=1.823,OR=6.187,95%CI:2.944~13.005),preoperative radiotherapy(β=2.611,OR=13.610,95%CI:2.914~63.572)and anastomposition(β=3.269,OR=26.286,95%CI:10.260~67.342)were independent risk factors affecting the occurrence of LARS after anal preservation surgery for rectal cancer(P<0.05).Conclusion LARS is a common complication after anal preservation of rectal cancer,and tumor location,preoperative radiotherapy and anastomotic position are all important factors affecting LARS after anal preservation,and attention should be paid in clinical intervention.
作者
张蕊
孙晓林
张光云
张秋月
ZHANG Rui;SUN Xiaolin;ZHANG Guangyun(Nanyang Central Hospital,Nanyang,473000)
出处
《实用癌症杂志》
2023年第7期1187-1189,1193,共4页
The Practical Journal of Cancer
关键词
直肠癌
保肛手术
低位前切除综合征
发生率
危险因素
Rectal cancer
Anal preservation surgery
Low pre-resection syndrome
Incidence
Risk factors
