摘要
目的研究半浸膏颗粒中饮片细粉含量对其物理性质和压缩性能的影响。方法以肠炎宁片为模型药物,测定含不同饮片细粉比例的肠炎宁颗粒的粉体学性质、压缩过程参数、抗张强度等指标,采用不同压缩方程对片剂抗张强度-压力、孔隙率-压力、抗张强度-孔隙率的变化规律进行拟合,阐明肠炎宁半浸膏片的成型机制,并用主成分分析对粉体学性质、压缩过程参数及拟合系数之间的相关性进行分析。结果当肠炎宁颗粒中的饮片细粉含量小于6%时,随着饮片细粉含量的增加,粒子间的结合力增强,粉体的成型性增强;当含量超过6%后,饮片细粉弹性作用增强,粒子间结合力减弱,抑制成型。结论从压缩成型角度说明了肠炎宁半浸膏片中饮片细粉含量的临界值为6%,可为半浸膏片的处方工艺优化提供较好的理论和实验依据。
Objective The purpose of this research was to investigate the effect of fine powder content of decoction pieces in semi-extract granules on its physical properties and compression properties.Methods The Changyanning Tablets were utilized as the model drug in this research.The powder properties,compression process parameters and tensile strength of Changyanning Granules with different fine powder contentwere characterized.The different compression equations were used to fit the variation patterns of tensile strength-pressure,porosity-pressure and tensile strength-porosity of the tablets to illustrate the tableting mechanism of semi-extract tablets.Principal component analysis was used to analyze the correlation between the powder properties,compression process parameters and the fitting coefficients.The correlation among powder properties,compression parameters and the fitting coefficients were analyzed by principal component analysis.Results The interparticle binding force increased within creasing the podwer content when the content of drinking powder was less than 6%,demonstrating that the tableting ability of Changyanning Granules was enhanced;When the content exceeded 6%,the elastic effect of fine powder increased and the interparticle binding force weakened,inhibiting the tableting.Conclusion This study illustrated the critical value of fine powder content of the tablets in Changyanning Tablets was 6%from the perspective of compression molding,suggesting that fine powder content of the tablets should be reasonably determined during the prescription process development of semi-extract tablets.
作者
潘浩敏
刘微
梁钧杰
饶小勇
张尧
余德发
李哲
罗晓健
PAN Hao-min;LIU Wei;LIANG Jun-jie;RAO Xiao-yong;ZHANG Yao;YU De-fa;LI Zhe;LUO Xiao-jian(Jiangxi University of Chinese Medicine,Nanchang 330004,China;National Engineering Research Center for Manufacturing Technology of Solid Preparation of Traditional Chinese Medicine,Nanchang 330006,China;Jiangxi CONBA Chinese Medicine Co.,Ltd.,Shangrao 334000,China)
出处
《中草药》
CAS
CSCD
北大核心
2023年第12期3842-3850,共9页
Chinese Traditional and Herbal Drugs
基金
江西省重大科技研发专项(20203ABC28W018)
上饶市科技计划项目(2021A002)。
关键词
半浸膏片
饮片细粉
压缩成型
主成分分析
肠炎宁
抗张强度
孔隙率
semi-extract tablets
fine powder
compression molding
principal component analysis
Changyanning
tensile strength
porosity
